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ProteomicsHuman UFSP1 is an active UFM1-specific protease
In order to confirm the translation initiation site of human UFSP1 (UFM1-specific protease 1), we sought to obtain direct evidence using mass spectrometry (MS) for peptide sequencing.
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD033083 | Pride
Ufmylation  ufm1-specific protease  ufsp1  ufsp2 
UnknownHuman UFSP1 translated from an upstream near-cognate initiation codon functions as an active UFM1-specific protease.
Not available
S-EPMC9168615 | biostudies-literature
UnknownAn ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.
Not available
S-EPMC3945108 | biostudies-literature
ProteomicsHuman UFSP1 is an active protease that regulates UFM1 maturation and UFMylation
An essential first step in the posttranslational modification of proteins with UFM1, UFMylation, is the proteolytic cleavage of pro-UFM1 to expose a C-terminal glycine. Of the two UFM1-specific proteases (UFSPs) identified in humans, only UFSP2 is reported to be active since the annotated sequence o...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD035142 | Pride
Ribosome Ufm1 Endoplasmic reticulum (er) Cysteine protease Ubiquitin like modifier 
UnknownHuman UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.
Not available
S-EPMC9638016 | biostudies-literature
UnknownStructure of ubiquitin-fold modifier 1-specific protease UfSP2.
Not available
S-EPMC3060479 | biostudies-literature
ProteomicsIdentification of interacting proteins for UFM1-specific protease 1 (UfSP1) using proximity labeling technique
In this project, we used label-free quantitative proteomics to identify UfSP1-interacting proteins in HEK293T cells.
ORGANISM(S): Homo Sapiens 
2023-01-31 | PXD039750 |
UnknownVariant of the catalytic cysteine of UFSP2 leads to spondyloepimetaphyseal dysplasia type Di Rocco.
Not available
S-EPMC10193157 | biostudies-literature
UnknownCharacterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex.
Not available
S-EPMC5665528 | biostudies-literature
ProteomicsAn Epstein–Barr Virus Protein Interaction Map Reveals NLRP3 Inflammasome Evasion Via MAVS UFMylation
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis and is associated with 200,000 cancers/year. EBV colonizes the B-cell compartment and periodically reactivates, inducing expression of 80 viral proteins. Yet much remains unknown about how EBV remodels host cells a...
ORGANISM(S): Viruses Homo sapiens (Human) 
2023-07-20 | PXD041336 | Pride
Innate immunity Gasdermin d Ufmylation Herpesvirus Mitochondrial-derived vesicles Herpesvirus replication Viral g-protein coupled receptor Nlrp3 inflammasome Antiviral defense Interactome Interleukin-1-beta 
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