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MetabolomicsMulti-omics analysis reveals ToMMV-induced regulation of amino acid and phenylpropanoid biosynthesis pathways affecting tomato fruit quality and resistance

Tomato mottle mosaic virus (ToMMV) is a major threat to cultivating tomatoes and other solanaceous plants. Here, an infectious clone of the ToMMV Huludao isolate was constructed, and ToMMV infection significantly reduces soluble sugar, soluble phenolic and vitamin C ...

2025-09-01 | MTBLS12864 | MetaboLights
TranscriptomicsComparative transcript profiling of plant virus synergism
Many virus diseases of economic importance to agriculture result from mixtures of different pathogens invading the host at a given time. This contrasts with the relatively scarce studies available on the molecular events associated with virus-host interactions in mixed infections. In comparison to s...
ORGANISM(S): Nicotiana benthamiana 
2010-05-16 | E-GEOD-15538 | biostudies-arrayexpress
TranscriptomicsExperiment comparing transcriptomes of red and purple tissue sections on Del/Ros1 Moneymaker fruit
Microarray analysis was used to compare the gene expression profiles of red and purple sectors of VIGS (Virus-induced gene silencing)-treated Del/Ros1 fruit in the MoneyMaker background. Fruit were silenced at the mature green stage and harvested at differing number of days after breaker. Custom two...
ORGANISM(S): Solanum lycopersicum 
2013-05-06 | E-GEOD-46341 | biostudies-arrayexpress
TranscriptomicsAntiviral RNA interference in mammalian cells
Plants and invertebrates protect themselves from viruses through RNA interference (RNAi), yet it remains unknown whether this defense mechanism exists in mammals. Antiviral RNAi involves the processing of viral long double-stranded (ds) RNA molecules into small interfering RNAs (siRNAs) by the ribon...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-43153 | biostudies-arrayexpress
TranscriptomicsPrinciples Governing Dicer-2 Substrate Selection are Revealed by Characterizing the RNAi Response to Virus Infection and Exogenous dsRNA
Background: RNA silencing pathways play critical roles in gene regulation, virus infection, and transposon control. RNA interference (RNAi) is mediated by small interfering RNAs (siRNAs), which are liberated from double stranded (ds) RNA precursors by Dicer and direct the RNA-induced silencing compl...
ORGANISM(S): Drosophila melanogaster 
2013-01-31 | E-GEOD-28957 | biostudies-arrayexpress
TranscriptomicsGlycine max Transcriptome or Gene expression
Virus Induced Gene Silencing (VIGS) was used to silence the expression of soybean Replication Protein 3 (GmRPA3). RNAseq was used to compare gene expression in GmRPA3 silenced and empty vector treated plants
ORGANISM(S): Glycine max 
2013-07-29 | E-MTAB-4354 | biostudies-arrayexpress
TranscriptomicsIdentification of RNase L-dependent, 3M-bM-^@M-2-end-modified, viral small RNAs in Sindbis virus-infected mammalian cells
Small RNAs play a critical role in host-pathogen interaction. In insects, for instance, small RNA-mediated silencing or RNA interference (RNAi) represents the main antiviral defense system. However, the antiviral role of RNAi has not been clearly proven in higher vertebrates. On the contrary, it is ...
ORGANISM(S): Chlorocebus aethiops 
2013-11-19 | E-GEOD-48831 | biostudies-arrayexpress
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
TranscriptomicsSequencing of small RNA libraries prepared from Invertebrate Iridescent Virus 6 (IIV6)-infected S2 cells or adult flies.
We observed several hundreds of thousand reads matching the IIV6 genome in IIV6 infected S2 and wild-type flies. The large majority of these reads have a size of 21 nt. This peak was absent from the library prepared from S2 non-infected and infected Dcr-2-/- mutant flies. The virus-derived siRNAs we...
ORGANISM(S): Invertebrate iridescent virus 6 
2013-02-06 | E-GEOD-41007 | biostudies-arrayexpress
TranscriptomicsExpression profiling in silencing suppressor plants or in mirna mutants-Transcriptional and post-transcriptional changes in Arabidopsis plants that constitutively express suppressors of RNA silencing
gen107_ptgs - gene profiling in silencing suppressor plants or in mirna mutants - What are the genes that are differentially regulated in various tissues derived from silencing suppressor plants or miRNA mutants? - HcPro, P15, P19, CHS-RNAi (control), were grown on MS solid medium, and tissues were ...
ORGANISM(S): Arabidopsis thaliana 
2011-08-22 | E-GEOD-26739 | biostudies-arrayexpress
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