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ProteomicsWnt signalosome assembly is governed by conformational flexibility of Axin and AP2 clathrin adaptor
Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic resonance spectroscopy to identify the membrane-proximal PPPSPxS motif an...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-04-30 | PXD061649 | Pride
Gsk3 inhibition  lrp6 co-receptor  axin scaffold protein  ap2 cargo adaptor  clathrin-coated structures  wnt signalosome 
UnknownTMEM88 Inhibits Wnt Signaling by Promoting Wnt Signalosome Localization to Multivesicular Bodies.
Not available
S-EPMC6700443 | biostudies-literature
UnknownWnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
Not available
S-EPMC5065529 | biostudies-literature
UnknownDishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly.
Not available
S-EPMC9811998 | biostudies-literature
UnknownAssembly and architecture of the Wnt/β-catenin signalosome at the membrane.
Not available
S-EPMC5727340 | biostudies-literature
ProteomicsWnt signaling recruits KIF2A to the spindle to ensure chromosome congression during mitosis
Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin-independent Wnt signaling is also required for faithful execution of mitosis. This mitotic Wnt signaling functions through Wnt-dependent stabiliz...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD022724 | Pride
Stem cell Kif2a Wnt/stop Kinesin-13 Mitosis Dishevelled Wnt signaling Plk1 Chromosome congression 
UnknownTMEM59 potentiates Wnt signaling by promoting signalosome formation.
Not available
S-EPMC5924918 | biostudies-literature
TranscriptomicsMITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by Glycogen Synthase Kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene MITF ...
ORGANISM(S): Homo sapiens 
2014-12-24 | E-GEOD-64497 | biostudies-arrayexpress
UnknownGATA4 regulates mesenchymal stem cells via direct transcriptional regulation of the WNT signalosome.
Not available
S-EPMC7855755 | biostudies-literature
UnknownWnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Not available
S-EPMC5458758 | biostudies-literature
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