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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
ProteomicsWnt signaling recruits KIF2A to the spindle to ensure chromosome congression during mitosis
Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin-independent Wnt signaling is also required for faithful execution of mitosis. This mitotic Wnt signaling functions through Wnt-dependent stabiliz...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD022724 | Pride
Stem cell Kif2a Wnt/stop Kinesin-13 Mitosis Dishevelled Wnt signaling Plk1 Chromosome congression 
GenomicsKIF2A stabilises intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis
KIF2A stabilises intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis
PRJNA957254 | ENA
GenomicsKif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 6 months]
Kif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 6 months]
PRJNA924036 | ENA
GenomicsKif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 1 month]
Kif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 1 month]
PRJNA1004224 | ENA
GenomicsKif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 3 months]
Kif2a operates as a gatekeeper of nociception in sensory neurons [RNA-seq - 3 months]
PRJNA924037 | ENA
TranscriptomicsKIF2A stabilises intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis
Cytokinesis, the final stage of cell division, serves to physically separate daughter cells. In cultured naïve mouse embryonic stem cells cytokinesis lasts unusually long. Here, we describe a novel function for the kinesin-13 member KIF2A in this process. In genome-engineered mouse embryonic stem ce...
ORGANISM(S): Mus musculus 
2025-05-06 | GSE230038 | GEO
UnknownKIF2A deficiency causes early-onset neurodegeneration.
Not available
S-EPMC9674219 | biostudies-literature
UnknownKIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation
Not available
S-EPMC9208156 | biostudies-literature
UnknownKIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.
Not available
S-EPMC5811213 | biostudies-literature
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