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UnknownMaternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.
Not available
S-EPMC4426427 | biostudies-literature
UnknownWnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells.
Not available
S-EPMC7723298 | biostudies-literature
TranscriptomicsThe Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficie...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20352 | biostudies-arrayexpress
ProteomicsWnt signaling recruits KIF2A to the spindle to ensure chromosome congression during mitosis
Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin-independent Wnt signaling is also required for faithful execution of mitosis. This mitotic Wnt signaling functions through Wnt-dependent stabiliz...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD022724 | Pride
Stem cell Kif2a Wnt/stop Kinesin-13 Mitosis Dishevelled Wnt signaling Plk1 Chromosome congression 
ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
TranscriptomicsExpression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling....
ORGANISM(S): Homo sapiens 
2017-02-04 | E-MTAB-4065 | biostudies-arrayexpress
ProteomicsReduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity
Loss-of-function mutations and deletions in the core components of the epigenetic polycomb repressive complex 2 (PRC2) are associated with poor initial treatment response in T-cell acute lymphoblastic leukemia (T-ALL), but the mechanisms that underpin resistance to individual therapies are unknown. ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD045010 | Pride
TranscriptomicsIdentifying early, intermediate, and late responses to GSK3a inhibition in Jurkat T-ALL cells in the presence or absence of an asparagine depletion
Amino acid availability is a crucial factor for survivability of cancer cells. Leukemia cells have been shown to resist asparagine depletion by utilizing GSK3-dependent proteasomal degradation, termed Wnt-dependent stabilization of proteins (Wnt/STOP), to replenish their amino acid pool. Inhibition ...
ORGANISM(S): Homo sapiens 
2023-09-13 | GSE234800 | GEO
TranscriptomicsEffect of asparagine depletion on Rspo3 fusion positive colorectal cancer cell organoid transcriptomes
Amino acid availability is a crucial factor for survivability of cancer cells. Colorectal cancer cells have been shown to resist asparagine depletion by utilizing GSK3-dependent proteasomal degradation, termed Wnt-dependent stabilization of proteins (Wnt/STOP), to replenish their amino acid pool. In...
ORGANISM(S): Mus musculus 
2023-09-13 | GSE234801 | GEO
UnknownMitotic WNT signalling orchestrates neurogenesis in the developing neocortex.
Not available
S-EPMC8488556 | biostudies-literature
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