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TranscriptomicsSynergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
The experiments were designed to interrogate the genetic interaction relationship between the TOR signalling pathway and the UPS-proteasome pathway in gene expression and cell growth. Yeast cells (BY4742pdr5delta) were treated with the drug vehicle, MG132 (50uM), rapamycin (200ng/ml) or both drugs. ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-24 | E-MTAB-1550 | biostudies-arrayexpress
ProteomicsNEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
SILAC quantitative mass spectrometry analysis on protein aggregates induced upon heat shock. Two separate performed analysis: A) control siRNA cells (light) with siRNA NEDD8 cells (heavy) and B) control cells (light) with MLN4924 treated cells (heavy). In all conditions cells were heat shocked at 43...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-17 | MSV000082623 | MassIVE
UnknownStructure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.
Not available
S-EPMC2980845 | biostudies-literature
TranscriptomicsSuppression of BRCA1 sensitizes to proteasome inhibitors in DNA repair-independent manner.
Germline and somatic mutations in BRCA1predispose to breast cancer. We found that proteasome inhibitors can selectively kill BRCA1-depleted cells. The toxic response involves a deregulation of the G1/S cell cycle checkpoint via hyperphosphorylation of RB1, 53BP1-mediated arrest at G2/M checkpoint, ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-56280 | biostudies-arrayexpress
UnknownRevealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach.
Not available
S-EPMC2577207 | biostudies-literature
UnknownInteraction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.
Not available
S-EPMC1138967 | biostudies-literature
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsTetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enzymatic uncoupling are determined by the NO synthas...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD010430 | Pride
Biotin switch S-nitrosylation 
UnknownASK1 negatively regulates the 26 S proteasome.
Not available
S-EPMC2978573 | biostudies-literature
TranscriptomicsTranscriptional Rewiring of IMR90 lung fibroblasts under Opposite Proteasome States
Stress Induced Premature Senescence in HDFs after altering proteasome activity (acronyms) GA = HDFs growth arrested at G0 PROT = senescent HDFs after proteasome Inhibition PbJ = HDFs transient transfection with the vector X = transient transfection with the B5 proteasome subunit
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-17124 | biostudies-arrayexpress
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