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Metabolomics1H HR-MAS NMR based metabolomics of cancer cells responding to two different doses of the diruthenium trithiolato complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1)
The trithiolato bridged diruthenium complex DiRu-1 [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ is highly cytotoxic against various cancer cell lines, but its exact mode of action remained unknown. The present 1H HR-MAS NMR based metabolomic study performed on the ovarian cancer cell lines A2780, its cisPt re...
2019-07-04 | MTBLS1014 | MetaboLights
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
GenomicsPseudonocardia sp. T1-2H
Pseudonocardia sp. T1-2H Genome sequencing and assembly
PRJNA1085046 | ENA
MetabolomicsIDH1R132H activity in glioma cell lines and tumnor tissue (2HG)
Not available
ORGANISM(S): Mus musculus 
ST000312 | MetabolomicsWorkbench
GenomicsCampylobacter jejuni strain:2H
Campylobacter jejuni strain:2H Genome sequencing
PRJNA1332499 | ENA
MetabolomicsLipidomics study of curcumin and epigallocatechin gallate on IgE-mediated degranulation of RBL-2H3 cells
Not available
ORGANISM(S): Rattus norvegicus 
ST002384 | MetabolomicsWorkbench
GenomicsThermoactinomyces vulgaris strain:2H
Thermoactinomyces vulgaris strain:2H Genome sequencing
PRJNA534300 | ENA
GenomicsFusarium oxysporum strain:FJB1-2H
Fusarium oxysporum strain:FJB1-2H Genome sequencing
PRJNA529944 | ENA
Metabolomics1H NMR metabolomics corroborates serine hydroxymethyltransferase as the primary target of 2-aminoacrylate in a ridA mutant of Salmonella enterica
Not available
ORGANISM(S): Salmonella enterica serovar Typhimurium 
ST001308 | MetabolomicsWorkbench
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