3-methylcytosine

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CHEBI:15971 (9)

Metabolite Name

3-Methylcytosine (16)
Niacinamide (12)
Guanine (12)
Inosine (12)
Methylimidazole acetaldehyde (11)
4-Hydroxybenzaldehyde (11)
L-Proline (11)
Hypoxanthine (11)
Uracil (10)
L-Histidinol (10)
5-Methylcytosine (10)
Proline betaine (10)
L-Histidine (10)
L-Arginine (10)
L-Glutamine (10)
Xanthine (10)
Guanosine (10)
Uridine (10)
L-Carnitine (10)
L-Isoleucine (10)
L-Phenylalanine (10)
Imidazole-4-acetaldehyde (9)
N-(5-Methyl-3-oxohexyl)alanine (9)
Lysyl-Glycine (9)
N6-Acetyl-L-lysine (9)
5-Hydroxyindoleacetic acid (9)
Prolylhydroxyproline (9)
Taurine (9)
3-Methoxytyrosine (9)
Adenosine (9)

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viruses (5)
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Lab affiliation

Babraham Institute (1)
Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, United States of America (1)
Department of Cancer Research and Molecular Medicine Faculty of Medicine Laboratory Centre, 5th floor. Erling Skjalgssons gt. 1 Norwegian University of Science and Technology NTNU 7006 Trondheim, Norway Tel: +47 72573076; Fax: +47 72576400 Cell. phone: +47 91825455 (1)
LMU Muenchen (1)
Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK (1)
University of Alabama at Birmingham (1)

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METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs

A subset of eukaryotic tRNAs is methylated in the anticodon loop to form the 3-methylcytosine (m3C) modification. In mammals, the number of tRNAs containing m3C has expanded to include mitochondrial (mt) tRNA-Ser-UGA and mt-tRNA-Thr-UGU. Whereas the enzymes catalyzing m3C formation in nuclear-encode...

ORGANISM(S): Homo sapiens (Human)

2022-05-19 | PXD030418 | Pride

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

Not available

S-EPMC3259822 | biostudies-literature

3,N4-Etheno-5-methylcytosine blocks TET1-3 oxidation but is repaired by ALKBH2, 3 and FTO.

Not available

S-EPMC11551763 | biostudies-literature

Direct enzymatic sequencing of 5-methylcytosine at single-base resolution [3]

PRJNA938127 | ENA

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells

Tet enzymes (Tet1/2/3) catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed in various embryonic and adult cell types. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete ...

ORGANISM(S): Mus musculus

2014-04-17 | E-GEOD-55049 | biostudies-arrayexpress

Characterization of Byproducts from Chemical Syntheses of Oligonucleotides Containing 1-Methyladenine and 3-Methylcytosine.

Not available

S-EPMC5709782 | biostudies-literature

Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs.

Not available

S-EPMC8980813 | biostudies-literature

DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.

Not available

S-EPMC7237682 | biostudies-literature

Structural impact of 3-methylcytosine modification on the anticodon stem of a neuronally-enriched arginine tRNA.