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ProteomicsMETTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs
A subset of eukaryotic tRNAs is methylated in the anticodon loop to form the 3-methylcytosine (m3C) modification. In mammals, the number of tRNAs containing m3C has expanded to include mitochondrial (mt) tRNA-Ser-UGA and mt-tRNA-Thr-UGU. Whereas the enzymes catalyzing m3C formation in nuclear-encode...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD030418 | Pride
Trna modification 3-methylcytosine Trna Mitochondria Mettl8 M3c 
GenomicsGlioblastoma stem cells after METTL8 knockdown.
Glioblastoma stem cells after METTL8 knockdown.
PRJNA788505 | ENA
TranscriptomicsGlioblastoma stem cells after METTL8 knockdown.
This project investigates the role METTL8 in human glioblastoma stem cells. In order to understand the transcriptomic changes upon deletion of METTL8, we performed this RNA seq and further downstream analyses to determine the pathways changed. From this, we hope to identify novel methods to target g...
ORGANISM(S): Homo sapiens 
2024-02-12 | GSE190804 | GEO
GenomicsThe Stat3 target Mettl8 regulates mouse ESCs differentiation via inhibiting JNK pathway
The Stat3 target Mettl8 regulates mouse ESCs differentiation via inhibiting JNK pathway
PRJNA445796 | ENA
GenomicsBalancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
PRJNA748058 | ENA
UnknownMolecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8.
Not available
S-EPMC9023283 | biostudies-literature
UnknownThe SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C.
Not available
S-EPMC7082549 | biostudies-literature
UnknownMETTL8 mRNA Methyltransferase Enhances Cancer Cell Migration via Direct Binding to ARID1A.
Not available
S-EPMC8196784 | biostudies-literature
UnknownMethyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs.
Not available
S-EPMC8980813 | biostudies-literature
GenomicsEpitranscriptomic regulation of cortical neural stem cell maintenance via Mettl8-dependent mitochondrial tRNA m3C modification
Epitranscriptomic regulation of cortical neural stem cell maintenance via Mettl8-dependent mitochondrial tRNA m3C modification
PRJNA885431 | ENA
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