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ProteomicsSmooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics
Our study aims to compare 2D adherent and 3D floating (spheroid) cell cultures of in the context of cellular physiology and in atherosclerosis modelling. Here, we utilize vascular smooth muscle cells from rat aorta to profile 2D and 3D proteomes.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-07 | PXD069144 | Pride
Smoot muscle cell  spheroids  3d cell culture  lc-ms/ms 
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
Proteomicsin vivo-like scaffold-free 3D in vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine
The study of muscle dystrophies, including Duchenne and Myotonic dystrophies, has faced significant challenges due to the lack of physiologically relevant in vitro models. This research introduces a novel, scaffold- and biomaterial-free platform based on cell sheet engineering to create in vitro mod...
ORGANISM(S): Homo sapiens (Human) 
2024-12-24 | PXD052728 | Pride
Drug treatment In vitro model Cell sheet engineering Scaffold-free Proteomics Dystrophy Skeletal muscle 
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
ProteomicsDevelopment of a 3D in vitro model of Dupuytren’s disease as a platform for drug screening
Background: Dupuytren’s disease (DD) is a common fibrotic disorder of the hand, characterized by progressive thickening and contracture of the palmar and digital fascia. Surgical excision remains the primary treatment; however, there are currently no therapies to prevent disease progression or recur...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD072354 | Pride
Myofibroblasts Proteomics Dupuytren’s disease 3d in vitro model Fibrosis Minoxidil Collagen type i Decellularization 
ProteomicsThe use of three-dimensional primary human myospheres to explore skeletal muscle effects of in vivo krill oil supplementation
Supplementation with krill oil has shown effects on whole-body lipid and glucose metabolism, as well as on skeletal muscle strength and function. The most widely used model for culturing skeletal muscle cells (myotubes) is two-dimensional (2D), however there is growing interest in establishing 3D mu...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD055840 | Pride
Label-free proteomics 3d muscle cell model Myosphere Krill oil 
ProteomicsBiofabrication of a 3D Human Skeletal Muscle Microenvironment to Study the Early Steps of Fibrosis
Skeletal muscle fibrosis is a prevalent characteristic of aging and dystrophies. Beyond myofibroblast involvement, recent findings highlighted a complex cellular cross-talk within the muscle microenvironment, finally resulting in vascular and tissue damage. This complexity is not captured by current...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD061757 | Pride
Biofabrication Endothelial-mesenchymal transition Microphysiological system Skeletal muscle Microvascular network 
ProteomicsOne-line-fits-all: a knockdown strategy for rapid, generic and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal-muscle
Humanized 3D-tissue-engineered-skeletal-muscles (3D-TESMs) offer advanced disease modelling, but their application often require isogenic controls and involves laborious and time consuming methodology. Here, by combining 3D-TESM and shRNA approaches, we developed a “one-line-fits-all” disease modell...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD042227 | Pride
Skeletal-muscle-on-a-chip Disease modelling 3d-organ-on-a-chip Duchenne’s muscular dystrophy Dystrophin Lgmd2a Calpain-3 Genetic knockdown Tissue engineering 
ProteomicsGeneration and Proteomic Analysis of Fibrin-Based 3D Engineered Vascular Tissues (EVTs) from Human Aortic Smooth Muscle Cells
Vascular smooth muscle cells (SMCs) reside within the medial layer of blood vessels, where they interact with an extracellular matrix (ECM) composed of collagen, elastin, and proteoglycans to maintain vascular structure and function. Aberrant ECM remodeling contributes to multiple vascular diseases;...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD080642 | Pride
Tissue engineering  3d cell culture smooth muscle cells  extracellular matrix  cardiovascular disease 
TranscriptomicsSignaling pathways in skeletal muscle of Amyotrophic Lateral Sclerosis mouse model
Gene expression analyses through cDNA microarray of fifteen gastrocnemius muscles from transgenic and wild-type SOD1G93A mouse model by the ages of 40 and 80 days old were performed. We used a customized cDNA array containing the cDNA platform comprised of 2352 spots, 326 of them orthologous to mous...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-40328 | biostudies-arrayexpress
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