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MetabolomicsLipidomic Comparison of 2D and 3D Colon Cancer Cell Culture Models
Not available
ORGANISM(S): Homo sapiens 
ST002070 | MetabolomicsWorkbench
ProteomicsShift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function
This project is described about the detailed characterization of 3D spheroid mesenchymal stem cells (MSCs). Specifically, authors showed the dynamic action towards EMT in 3D MSCs and the potential of EMT-enhanced “naïve” mesenchymal phenotype.
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD006653 | Pride
Human Cell 3d-cultured Mesenchymal stem cell Lc-ms/ms 
TranscriptomicsChanges in Global Gene Expression Associated with 3D Structure of Tumors: an ex vivo Matrix-Free Mesothelioma Spheroid Model
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in multicellular tumor microenvironments, however, are difficult to study ex vivo. Here, we generated a matrix-free tumor spheroid model using the NCI-H226 mesothelioma cell line and compared the gene expre...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-37629 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
TGFbeta/TNFalpha treated spheroid A549 cultures are a model of the epithelial-mesenchymal transition (EMT). These experiments capture the changes in global gene expression that result from cells being induced to undergo EMT (3D control vs 3D treated), but also the differences in gene expression when...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42373 | biostudies-arrayexpress
ProteomicsSmooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics
Our study aims to compare 2D adherent and 3D floating (spheroid) cell cultures of in the context of cellular physiology and in atherosclerosis modelling. Here, we utilize vascular smooth muscle cells from rat aorta to profile 2D and 3D proteomes.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-07 | PXD069144 | Pride
Smoot muscle cell  spheroids  3d cell culture  lc-ms/ms 
Genomics3D spheroid culture to examine adaptive therapy response in invading tumor cells
3D spheroid culture to examine adaptive therapy response in invading tumor cells
PRJNA890561 | ENA
GenomicsHistone modification analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
We studied the extent of chromatin remodeling in an in-vitro model of the epithelial-mesenchymal transition (EMT). EMT is induced in spheroid cultures (3D) using simultaneously two cytokines: TGFbeta and TNFalpha. The epithelial-mesenchymal transition (EMT) is a cellular de-differentiation process t...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42374 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of Bioprinted 3D Lung Spheroid Model Mimicking Tumor Microenvironment
Transcriptomic analysis of Bioprinted 3D Lung Spheroid Model Mimicking Tumor Microenvironment
PRJNA1269475 | ENA
ProteomicsConditions for maintenance of hepatocyte differentiation and function in 3D cultures
3D spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. However, the 3D spheroids are maintained under different conditions, with possible cofounding results. Here we performed an in-depth analysis of how various culture conditions influen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024632 | Pride
Primary human hepatocyte culture Lc-ms/ms 
GenomicsTranscriptomic Profiling of adherent (2D) and spheroid (3D) cultures of SW480 colorectal cancer cells
Transcriptomic Profiling of adherent (2D) and spheroid (3D) cultures of SW480 colorectal cancer cells
PRJNA1521346 | ENA
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