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TranscriptomicsPPARg dependent expression changes during differentiation of 3T3L1 cell into adipocytes
We profiled PPARg dependent gene expression changes during differntiation of 3T3L1 cell using PPARg siRNA 3T3-L1 (Pre-adipocyte) cell line was induced to differentiate using standard adipocyte differentiation media (IBMX, Dex and Insulin) 48hrs post-confluency. RNA was harvested at day -2 (confluent...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-12929 | biostudies-arrayexpress
ProteomicsMS proteomic datasets for "Development of methodology to investigate the surface SMALPome of mammalian cells".
In this study, mass spectrometry proteomics was used to investigate whether there are qualitative or quantitative differences in the mammalian plasma membrane proteins extracted with SMA compared to a detergent control. For this, cell surface proteins of 3T3L1 fibroblasts were biotinylated and extr...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-15 | PXD027735 | Pride
Mouse 3t3l1 fibroblasts Nano-lc-ms 
TranscriptomicsPPARg dependent expression changes during differentiation of 3T3L1 cell into adipocytes
We profiled PPARg dependent gene expression changes during differntiation of 3T3L1 cell using PPARg siRNA 3T3-L1 (Pre-adipocyte) cell line was induced to differentiate using standard adipocyte differentiation media (IBMX, Dex and Insulin) 48hrs post-confluency. RNA was harvested at day -2 (confluent...
ORGANISM(S): Mus musculus 
2009-03-24 | GSE12929 | GEO
GenomicsMus musculus
PPARg dependent expression changes during differentiation of 3T3L1 cell into adipocytes
PRJNA110849 | ENA
ProteomicsProteomic characterization of the role of Snail1 in the differentiation of 3T3-L1 fibroblasts
Snail1 is a transcriptional repressor required for a correct embryonic development. In cancer, Snail1 promotes the epithelial to mesenchymal transition in tumorigenic epithelial cells. In this work, we have analyzed the control of Snail1 in the differentiation of the 3T3-L1 cell line derived from mu...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-06 | PXD001529 | Pride
Adipogenesis Il-17 Obesity Nr2f6 Snail Silac Ltq orbitrap velos 
TranscriptomicsGene expression data from differentiating 3T3-L1 cells
The MED1 subunit has been shown to mediate ligand-dependent binding of the Mediator coactivator complex to multiple nuclear receptors, including the adipogenic PPARγ, and to play an essential role in ectopic PPARγ-induced adipogenesis of mouse embryonic fibroblasts. However, the precise roles of MED...
ORGANISM(S): Mus musculus 
2023-09-14 | GSE158083 | GEO
UnknownCritical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.
Not available
S-EPMC8091968 | biostudies-literature
GenomicsBET bromodomain proteins regulate enhancer function during adipogenesis
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in expression of PPARg and C/EBPa, which orchestrate activation of the adipocyte gene expression program. However, the coactivators controlling PPARg and C/EBPa ...
ORGANISM(S): Mus musculus 
2018-03-07 | GSE109940 | GEO
UnknownBET bromodomain proteins regulate enhancer function during adipogenesis.
Not available
S-EPMC5834672 | biostudies-literature
ProteomicsPervasive Roles of Ubiquitination in Orchestrating the Deubiquitinase Activity and Function of the BAP1/ASXL2 Tumor Suppressor Complex
The tumor suppressor and deubiquitinase (DUB) BAP1 regulates chromatin-associated processes and is frequently mutated in various malignancies. BAP1 and its drosophila orthologue Calypso assemble DUB complexes with ASXL-1, -2, -3 paralogues and ASX respectively, and these cofactors are required for s...
ORGANISM(S): Homo sapiens (Human) 
2018-09-28 | PXD011124 | Pride
Histone h2ak119ub  deubiquitination Polycomb group proteins  bap1  calypso  asxl  cell proliferation 
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