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MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsDm Snail Affymetrix ChIP
Genomewide mapping of D. melanogaster Snail protein binding during embryonic development at 2-4 hrs after egg-laying. Two independent repeats were assayed and preimmune-serum was used as a control. The enriched DNA was hybridized to high density Affymetrix GeneChip Drosophila Tiling 1.0R array
ORGANISM(S): Drosophila melanogaster 
2014-01-10 | E-MTAB-1589 | biostudies-arrayexpress
TranscriptomicsD. melanogaster gene expression profiling time course of Snail mutants
Expression profiling of Drosophila melanogaster halo[AJ] snail[Df(2L)TE116GW11] and halo[AJ] sna[V2] homozygous mutant embryos at two timepoints of embryogenesis. Embryos were manually sorted and assayed at cellularisation stage (stage 5 to early stage 6) and at gastrulation stage (late stage 6 to e...
ORGANISM(S): Drosophila melanogaster 
2014-01-10 | E-MTAB-1598 | biostudies-arrayexpress
TranscriptomicsStudy of stem cells and progenitor cells in K14 Snail mice
Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during progression of epithelial cancer, we used a mouse model with skin-specific overexpression of Snail. Snail transgenic mice spontaneously developed distinct...
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-48859 | biostudies-arrayexpress
TranscriptomicsTwist, Snail and Zeb1 targets in the context of TrkB
RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1
ORGANISM(S): Rattus norvegicus 
2011-10-12 | E-MTAB-456 | biostudies-arrayexpress
ProteomicsEMT induction in MCF7 cells by overexpression of SNAIL transcription factor
The human breast cancer cell line MCF7 was trasnduced with SNAIL trasncription factor. In-depth proteomic analysis revealed several important cellular processes regulated, especially related to epigenetic control of cell proliferation and protein expression.
ORGANISM(S): Homo sapiens (Human) 
2016-01-20 | PXD002449 | Pride
Human Mcf7 Emt Breast cancer Snail 
TranscriptomicsExpression data from Snail over-expressing non-small cell lung cancer cell lines
Snail is a zinc-finger transcription factor best known for its ability to down-regulate E-cadherin. Its established significance in embryology and organogenesis has been expanded to include a role in the tumor progression of a number of human cancers. In addition to E-cadherin, it has more recently ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16194 | biostudies-arrayexpress
TranscriptomicsThe mRNA expression of FaDu-Ctrl, FaDu-Snail, FaDu-Snail2R cells
To screen the genes regulated by wt-Snail and non-acetylated Snail The successful development of cancer metastasis requires two major events: the reprogramming of cancer cells to increase their migration and tumor-initiation capabilities; and the remodeling of the tumor microenvironment to facilitat...
ORGANISM(S): Homo sapiens 
2014-08-16 | E-GEOD-58592 | biostudies-arrayexpress
TranscriptomicsNetwork Understanding of SNAIL inhibitor induced perturbations in EMT models
Two engineered HMLE cell lines representing various degrees of EMT were treated with a drug in development to target and inhibit SNAIL interaction with PTP53, called GN-25 total RNA was isolated and analyzed in an Agilent two-color experiment. Four biological replicates of each condition were direct...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-44397 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiating Flk1- and Flk1+ ES cells expressing Snail during Wnt inhibition
ES cells differentiated in the presence of the Wnt inhibitor DKK1 fail to express the transcription factor Snail and undergo EMT or mesoderm differentiation. We generated an ES cell line, A2.snail, that induced Snail expression upon addition of doxycycline addition. Microarrays were used to gain a ...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-26524 | biostudies-arrayexpress
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