Sort   by:  
 Page size 
MetabolomicsHigh-dose capsaicin exacerbates uveitis by disrupting intestinal ho-meostasis and upregulating IL-17
Purpose: To determine whether capsaicin (CAP) exacerbates experimental autoimmune uveitis (EAU) and whether this effect is associated with impaired intestinal homeostasis, gut microbiota re-modeling, and altered metabolic profiles. Methods: An EAU mouse model was used to evaluate the dose-dependent ...
2026-07-23 | MTBLS15144 | MetaboLights
MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
TranscriptomicsIL-17-induced NF-kB activation via CIKS/Act1: Physiologic significance and signaling mechanisms
Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of the adaptor protein CIKS/Act1 ...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-24873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human aortic vascular smooth muscle cells treated with IL-17 or untreated
Investigate the effect of recombinant human IL-17A on vascular smooth muscle cells cultured from human aortas. Experiment Overall Design: SMCs from the aortas of three different donors were cultured in M199 media supplemented with 20% FCS and used at passage 3. The cells were either not treated or t...
ORGANISM(S): Homo sapiens 
2008-10-24 | E-GEOD-11367 | biostudies-arrayexpress
TranscriptomicsIntegrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
We sought to provide a comprehensive evaluation of the effects of TNF-α and IL-17 on the keratinocyte gene profile in order to identify genes that might be co-regulated by these cytokines. We then sought to determine how genes that were synergistically activated by both cytokines relate to the psori...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-24767 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse ileum to investigate the role of IL-17 receptor signaling in Paneth cells in their biology and intestinal physiology
IL-17 receptor plays a major role in the antibacterial defense and regulation of host-microbiota interaction. However its impact on Paneth cells, cell-type specific for production of antibacterial peptides, is still not clear. Here, we used genetic depletion of IL-17 receptor specific for Paneth cel...
ORGANISM(S): Mus musculus 
2022-01-01 | E-MTAB-10038 | biostudies-arrayexpress
ModelsImmunological Model of sphingolipids with IL-6/IL-17/IL-23 in L. major infection
In diseased state, we demonstrated that increase in production of sphingosine-1-phosphate and overexpression of IL-6,lL-17 and IL-23 with SATB1 leads to disease progression.
2023-01-11 | MODEL2301110001 | BioModels
ModelsImmunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection
In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation.
2023-01-11 | MODEL2301110002 | BioModels
ProteomicsMeningeal γδ T cells producing IL-17 control synaptic plasticity and cognitive behaviour
The conventional notion of “immune privilege” of the brain has been revised to accommodate its infiltration, at steady state, by immune cells that participate in normal neurophysiology (Louveau, Trends Immunol 2015; Kipnis science 2016; Filiano, Nat Rev Neurosciences 2017). Surprisingly, such neuroi...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-16 | PXD007574 | Pride
Swath Il-17 Γδ t cells 
ProteomicsSystematic analysis of IL-17 receptor signalosome reveals a robust regulatory feedback loop
IL-17 mediates immune protection from fungi and bacteria as well as it promotes autoimmune pathologies. However, the regulation of the signal transduction from the IL-17 receptor (IL-17R) remained elusive. We developed a novel mass spectrometry-based approach to identify components of the IL-17R com...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-15 | PXD019020 | Pride
Traf6 Lubac   Il-17 Ikkε Tbk1 
Sort   by:  
 Page size