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Proteomics4-HNE modification of human recombinant Dicer
We used mass spectrometry analysis (nanoLC-MS/MS) to map 4-HNE-modified residues of human Dicer exposed in vitro to 4-HNE in a concentration-dependent maner
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD034113 | Pride
Human dicer 4-hne Lc-ms/ms 
TranscriptomicsEffect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
4-Hydroxynonenal (HNE), a cytotoxic and diffusible electrophile generated by the spontaneous decomposition of oxidized lipids, has a suspected role in neurodegenerative and inflammatory disease processes. In addition to promoting cell death, elevated levels of HNE lead to the engagement of cytoprote...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-12762 | biostudies-arrayexpress
Genomics4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
PRJNA631421 | ENA
TranscriptomicsTranscription profiling time series of human RKO cell line responses to 2-hydroxy-2-nonenal
Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2397 | biostudies-arrayexpress
ProteomicsLC-MS/MS data of specific proteins involved 4-HNE modification in bone formation
To elucidate the specific proteins involved in bone formation that are modified by 4-HNE, we performed LC-MS-based proteomics analysis. This approach identified several candidate proteins, including MAP kinase-activated protein kinase 3 (MAPK3), plastin-3 (PLS3), and integrin-linked protein kinase (...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-26 | MSV000096541 | MassIVE
TranscriptomicsTranscription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls
HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2298 | biostudies-arrayexpress
Transcriptomics4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
Pathogens must counteract a wide array of antimicrobial responses, including the reactive oxygen species (ROS) burst. ROS mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) leads to the production of the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). 4-HNE has been stud...
ORGANISM(S): Listeria monocytogenes 10403S 
2020-05-10 | GSE150188 | GEO
UnknownALDH2 protects against stroke by clearing 4-HNE.
Not available
S-EPMC3698638 | biostudies-literature
TranscriptomicsGene expression for transformed YAMC clones
YAMC murine colonic epithelial cells were repeatitively treated with commensal bacteria-polarized macrophages or 4-HNE. Following 10 treatments, 25 clones were selected to engraft immunodeficient mice, and 10 out of 25 clones grew tumors in these mice. To explore gene expression associated with cell...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-55233 | biostudies-arrayexpress
UnknownRegulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma.
Not available
S-EPMC10452552 | biostudies-literature
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