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MetabolomicsIntegrative Analysis of Trichosanthes kirilowii Maxim Formula Granules’ AntiTriple-Negative Breast Cancer Mechanism via Network Pharmacology, Metabolomics, and Molecular Pharmacology

Background: Triple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology, metabolomics, and molecular pharmacology to cla...

2026-02-15 | MTBLS13902 | MetaboLights
ProteomicsProteomic analysis of extracellular vesicles (EVs) from 4T1 breast cancer cells upon paclitaxel treatment
Increasing pre-clinical data suggest that chemotherapy may elicit pro-metastatic responses in breast cancer models. Primary tumours release extracellular vesicles (EVs) that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on pro-met...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-02 | PXD010362 | Pride
4t1 Extracellular vesicles Paclitaxel 
TranscriptomicsRNA-seq of 4T1 mouse breast cancer cells cultured on soft vs stiff polyacrylamide hydrogels for 24 hours
The tumour microenvironment is a critical element involved in tumour progression and responsiveness to therapies. Using functionalized tunable stiffness hydrogel, mimicking the mechanical properties of healthy and tumour tissues, we explore how the stiffness of the microenvironment can influence can...
ORGANISM(S): Mus musculus 
2024-12-30 | E-MTAB-11487 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 cells and 4T1 tumors
This SuperSeries is composed of the following subset Series: GSE19220: Expression data from TKI258 treated 4T1 cells GSE19221: Expression data from TKI258 treated 4T1 tumors Refer to individual Series
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19222 | biostudies-arrayexpress
TranscriptomicsExpression data from adult mice breast cancer cell 4T1
Microaaray data for CD44v8-10-positive / CD44v8-10-negative 4T1 cancer cells (mouse breast cancer cells) We used microarrays to detail the global programming of gene expression of 4T1 cells depending on whether CD44v is present or not. 4T1 cells, one of the mouse breast cancer cells, were selected f...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-35803 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 cells
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on the proliferation and survival of these cells. We used microarray to understand the contribution of FGFR sig...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19220 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 tumors
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on 4T1 tumors in-vivo. We used microarray to understand the contribution of FGFR signaling to the tumor formati...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19221 | biostudies-arrayexpress
ProteomicsProteomic analysis of the secretome from 4T1 breast cancer cells upon Stat3 silencing.
Stat3 has been acknowledged as an oncogene that has dual protumorigenic activity in a cell-intrinsic way, by promoting cancer cell proliferation and survival and in a paracrine mode, acting as suppressor of immune cell attack. We demonstrated that Stat3 silencing with a small interfering RNA (siRNA)...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD013948 | Pride
4t1 Stat3 Secretome 
TranscriptomicsSingle cell RNA-seq of an native and engineered metastatic niche in a metastatic breast cancer murine model
Metastatic lesions are typically not found until patients self-report symptoms or they become radiologically evident. We have developed an engineered metastatic niche (scaffold) that recruits aggressive tumor cells prior to their colonization in other organs. The engineered niche can be monitored fo...
ORGANISM(S): Mus musculus 
2022-08-02 | E-MTAB-8503 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of mouse mammary tumor cell lines with different metastatic abilities
Compare miRNA expression profiles in isogenic mouse mammary tumor cell lines (67NR, 168FARN, 4TO7, 4T1) with different metastatic abilities
ORGANISM(S): Mus musculus 
2010-03-22 | E-MEXP-2289 | biostudies-arrayexpress
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