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TranscriptomicsGene Expression in Human Lung Type II Cells
Normal lung function relies on mature function of alveolar type II cels, which have numerous functions including to regulate ion and fluid flux, produce immune molecules, and synthesize and secrete surfactant to stabilize air spaces. Differentiation of type II cells from precursor epithelial cells ...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-19699 | biostudies-arrayexpress
Proteomics3’,5’-cAMP affects actin cytoskeleton dynamics by direct binding to actin.
Cyclic adenosine monophosphate (3’,5’-cAMP) is a well-characterized and evolutionary conserved second messenger. In contrast to the animal cells, however, the role of 3’,5’-cAMP in plants remains enigmatic. With the exception of cyclic nucleotide-gated ion channels, no plant 3’,5’-cAMP interactors h...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-06-02 | PXD019537 | Pride
Camp Actin Cytoskeleton Arabidopsis thaliana Signalling 
TranscriptomicsTranscription profiling of mouse S49 cells to study the global impact of cAMP and protein kinase A on gene expression
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A (PKA), on gene expression is not known. Here we show that treatment of wild-type S49 lymphoma cells for 24 h with 8-(4-chlorophenylthio)-cAM...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2413 | biostudies-arrayexpress
GenomicscAMP and mGluR1/5 dependent expression of mRNA, lncRNA, and miRNA in mouse hippocampal neurons
cAMP and mGluR1/5 dependent expression of mRNA, lncRNA, and miRNA in mouse hippocampal neurons
PRJNA675483 | ENA
TranscriptomicsGenomic analysis of SRC-2/TIF2 regulated genes in breast cancer cells_
We have characterized the global program of transcription in SRC-2-depleted MCF-7 breast cancer cells using short-hairpin RNA technology, and in MCF-7 cells exposed to PKA activating agents. In order to identify genes that may be regulated through PKA-induced downregulation of SRC-2, overlapping tra...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-MTAB-1662 | biostudies-arrayexpress
ProteomicsProtein interactome of 3’,5’-cyclic adenosine monophosphate reveals its role in regulating the actin cytoskeleton
Four biological replicates of Arabidopsis seedlings supplemented with 1 µM Br-3’,5’-cAMP, or water (control) were subjected to untargeted proteomics analysis at two time-points: 30 min and 1 h. Rather than wild-type, we used act2act7 mutant because of the evident phenotypic changes associated with t...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-05-22 | PXD030124 | Pride
Abp Thermal proteome profiling Cytoskeleton 5'-camp 3' Actin Hypocotyl growth 
TranscriptomicsTranscription profiling of mouse S49 lymphoma cell deathless (D-) cell variant
The second messenger cAMP acts via protein kinase A (PKA) to induce apoptosis by mechanisms that are poorly understood. Here, we assessed a role for mitochondria and analyzed gene expression in cAMP/PKA-promoted apoptosis by comparing wild-type (WT) S49 lymphoma cells and the S49 variant, D- (cAMP-d...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9727 | biostudies-arrayexpress
TranscriptomicsPro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells
Human mesenchymal stromal cells (hMSCs) are able to differentiate into a wide variety of cell types, which makes them an interesting source for tissue engineering applications. On the other hand, these cells also secrete a broad panel of growth factors and cytokines that can exert trophic effects on...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7224 | biostudies-arrayexpress
UnknownA 3',5' cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd.
Not available
S-EPMC107447 | biostudies-literature
UnknownExpression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex.
Not available
S-EPMC2632089 | biostudies-literature
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