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ProteomicsChemoproteomic Profiling of Reactive Cysteines in Response to Oxidative Stress Induced by 6-Hydroxydopamine
Oxidative stress is a well-known driver of neurodegeneration, yet it remains poorly understood how the global cysteine (Cys) proteome is remodeled in such conditions. Proteins with aberrantly modified Cys in response to oxidative stress can induce and exacerbate neurodegeneration. In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD060980 | Pride
Quantitative proteomics Cell stress response Sh-sy5y Oxidative stress Neurodegeneration Neurodegenerative signaling 6-hydroxydopamine Cysteine proteomics 
Genomics6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation
6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation
PRJNA1304260 | ENA
Transcriptomics6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation
Chronic stress activates the sympathetic nervous system (SNS) and has been linked to cancer progression, yet the role of SNS in cancer remains controversial. To investigate sympathetic regulation of cancer, we use genetic, pharmacological (6-hydroxydopamine, 6-OHDA) and surgical sympathetic ablation...
ORGANISM(S): Mus musculus 
2026-03-18 | GSE305030 | GEO
TranscriptomicsTranscriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydop...
ORGANISM(S): Rattus norvegicus 
2010-09-21 | GSE24233 | GEO
UnknownDifferences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson's disease models.
Not available
S-EPMC6065241 | biostudies-literature
TranscriptomicsTranscriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydop...
ORGANISM(S): Rattus norvegicus 
2010-09-21 | E-GEOD-24233 | biostudies-arrayexpress
UnknownOxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione.
Not available
S-EPMC3221727 | biostudies-literature
UnknownErgothioneine Prevents Neuronal Cell Death Caused by the Neurotoxin 6-Hydroxydopamine.
Not available
S-EPMC10854700 | biostudies-literature
UnknownMethamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats.
Not available
S-EPMC3001483 | biostudies-literature
TranscriptomicsTime Course of Gene Expression in the Substantia Nigra in Response to Intrastriatal 6-hydroxydopamine in the rat.
The 6-hydroxydopamine (6OHDA) rat model of parkinsonism is among the first, and most commonly used, animal models of Parkinson’s disease. It provides insight into the compensatory changes that occur in the brain after dopamine (DA) neuron degeneration. In order to better define the consequences of s...
ORGANISM(S): Rattus norvegicus 
2014-06-21 | GSE58710 | GEO
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