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UnknownAntibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy.
Not available
S-EPMC2661425 | biostudies-literature
ProteomicsShotgun proteomic elucidation of Synergistic mechanisms of Cannabidiol and SN-38 in the MCF7 cells
We evaluted the synergyistic interactions of cannabidiol (CBD) with standard chemotherapeutic agents such as Docetaxel (DOC), doxorubicin (DOX), paclitaxel (PTX), vinorelbine (VIN), and 7-Ethyl-10-hydroxycamptothecin (SN38) in MCf7 cells ultising different synergy metrics. Then we explored the syner...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026587 | Pride
Breast cancer Proteomics Mcf7 Synergy Cannabidiol Sn-38 Cbd 7-ethyl-10-hydroxycamptothecin 
UnknownCo-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects.
Not available
S-EPMC6964270 | biostudies-literature
UnknownCase Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth.
Not available
S-EPMC8117000 | biostudies-literature
UnknownOvercoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines.
Not available
S-EPMC2574763 | biostudies-literature
UnknownDevelopment of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation.
Not available
S-EPMC7032223 | biostudies-literature
TranscriptomicsGene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major ...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-62080 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of topoisomerase I inhibitor irinotecan (CPT-11) sensitive, resistant, and reverted human neuroblastomas
We have established a neuroblastoma model resistant in vivo to the topoisomerase I inhibitor irinotecan (CPT-11, Camptothecin-11, CAMPTOSAR®) in order to study resistance to these agents acquired in a therapeutic setting. Common mechanisms of resistance were not involved in this model and we thus ex...
ORGANISM(S): Homo sapiens 
2008-01-26 | E-TABM-211 | biostudies-arrayexpress
TranscriptomicsExpression data from Irinotecan resistant LoVo cells comapred to parental LoVo cells
Irinotecan, an analogue of camptothecin, is frequently used in combination with various anticancer drugs or as a single agent in treatment of colorectal cancer. But drug resistance of tumor is still a major obstacle to overcome for the success of cancer treatment. In this study, We established chron...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-59501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat intestine to investigate Irinotecan-induced changes
The regional specificity and timing of gene activation following chemotherapy, and how this relates to subsequent mucositis development is currently unknown. The aim of the study was therefore to determine the early time course of gene expression changes along the gastrointestinal tract (GIT) of th...
ORGANISM(S): Rattus norvegicus 
2008-10-21 | E-GEOD-11722 | biostudies-arrayexpress
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