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ProteomicsFast & High Throughput LC-MS Characterization, and Peptide Mapping of Engineered AAV Capsids Using LC-MS/MS
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With a skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterization plays an important role in serotype confirmation ...
ORGANISM(S): Adeno-associated virus 9 
2023-03-11 | PXD035837 | Pride
Peptide map. Aav capsids Engineered aav capsids Lcms Msms 
GenomicsAAV Assembled Capsids Are Produced in Cells Blocked fromFrom Cell Cycle Progression
AAV Assembled Capsids Are Produced in Cells Blocked fromFrom Cell Cycle Progression
PRJNA1155159 | ENA
ProteomicsAAV Orbitrap CD-MS for AAV2, AAV6, and AAV8
CD-MS analysis collected on an Orbitrap UHMR. Note, this data was collected on a beta version of the DMT software and thus contains STORI files stored in separate zip files. The DMT files are also included as supplemental files, along with the UniDecCD processing parameters.
ORGANISM(S): Adeno-associated Dependoparvovirus A (ncbitaxon:1511891) 
2023-04-05 | MSV000091650 | MassIVE
TranscriptomicsAAV Assembled Capsids Are Produced in Cells Blocked fromFrom Cell Cycle Progression
Adeno-associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/d...
ORGANISM(S): Homo sapiens 
2025-11-21 | GSE276141 | GEO
ProteomicsComplement activation by AAV-neutralizing antibody complexes
IP-MS analysis of AAV9 empty capsid protein-protein interactions with serum from healthy human donors.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-09 | MSV000091454 | MassIVE
ProteomicsAnalysis of Protein Carrier AAV by LC-MS/MS
AAV is widely used for efficient delivery of DNA payloads. The extent to which the AAV capsid can be used to deliver a protein payload is unexplored. Here, we report engineered AAV capsids that directly package proteins – Protein Carrier AAV (pcAAV). Nanobodies inserted into the interior of the caps...
ORGANISM(S): Adeno-associated virus 2 Srivastava/1982 
2025-05-07 | PXD054767 | Pride
Lc-msms Adeno-associated virus Dia Maxquant 
UnknownThe amazing AAV capsids: Into the structure-verse.
Not available
S-EPMC12682079 | biostudies-literature
UnknownThe HLA class-II immunopeptidomes of AAV capsids proteins.
Not available
S-EPMC9807805 | biostudies-literature
UnknownAAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression.
Not available
S-EPMC12779224 | biostudies-literature
UnknownRationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS.
Not available
S-EPMC5503098 | biostudies-literature
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