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ProteomicsSILAC analysis of proteins enriched from LNCaP cells by ABE
The study was to identify candidate S-acylated proteins from LNCaP cells by coupling SILAC quantification with ABE enrichment of S-acylated proteins and GeLC-MS/MS analysis. Another goal is to determine the ratio of candidate S-acylated proteins versus of co-isolated non-S-acylated proteins.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013189 | Pride
Silac  prostate cancer  lncap  abe  palmitoylation  s-acylation  palmitoyl-proteomics 
TranscriptomicsThe cold-induced two-component system CBO0366/CBO0365 regulates metabolic pathways with novel roles in cold tolerance of Group I Clostridium botulinum ATCC 3502
The two-component system CBO0366/CBO0365 was recently demonstrated to have a role in cold tolerance of Group I Clostridium botulinum ATCC 3502. The mechanisms under its control, ultimately resulting in increased sensitivity to low temperature, are unknown. A transcriptomic analysis with DNA microarr...
ORGANISM(S): Clostridium botulinum A str. ATCC 3502 
2013-10-29 | E-GEOD-26587 | biostudies-arrayexpress
ProteomicsS-acylproteomic analysis of human prostate cancer LNCaP cells by LB-ABE
Deep S-acylproteomic analysis of LNCaP cells by coupling LB-ABE with label-free quantitative proteomics
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013187 | Pride
Palmitoylation  s-acylation  palmitoyl-proteomics  s-acylproteomics  lncap  lb-abe 
TranscriptomicsEffect of Lactobacillus brevis 119-2 isolated from turnip M-bM-^@M-^\Tsuda kabuM-bM-^@M-^] on hepatic cholesterol level in cholesterol-administrated rat
In previous in vitro study, we reported potential mechanism of cholesterol-lowering effect of Lactobacillus brevis119-2 (119-2) isolated from turnip M-bM-^@M-^\Tsuda kabuM-bM-^@M-^] is due to incorporation of cholesterol into 119-2 cell. In this study, we analyzed serum cholesterol and hepatic gene ...
ORGANISM(S): Rattus norvegicus 
2013-04-24 | E-GEOD-41734 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of labial salivary glands in IgG4-related disease M-bM-^@M-^S comparison with SjM-CM-6grenM-bM-^@M-^Ys syndrome
To compare gene expression in labial salivary glands (LSG) of IgG4-related disease (IgG4-RD) with SjM-CM-6grenM-bM-^@M-^Ys syndrome (SS). Gene expression was analyzed by DNA microarray in LSG of IgG4-RD (n=5), SS (n=5), and healthy controls (n=3). Differentially expressed genes...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-40568 | biostudies-arrayexpress
ProteomicsProteome-wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights into Early Immune Signaling
To understand protein S-palmitoylation's role in macrophage reprogramming, dynamic changes were comprehensively mapped in immortalized mouse macrophages during early LPS stimulation using acyl-biotin exchange (ABE) proteomics enhanced with multi-protease digestion. This approach identified 2613 puta...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD063463 | Pride
Macrophage Acyl-biotin exchange (abe) Palmitoylation Immune signaling S-acylation Post-translational modification Lipopolysaccharide (lps) Multi-protease digestion Proteomics 
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
TranscriptomicsIpsA, a novel transcriptional regulator required for inositol derived lipid formation in Corynebacteria and Mycobacteria
The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well unde...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-01-13 | E-GEOD-50210 | biostudies-arrayexpress
TranscriptomicsComplex regulation of the PEP carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
DNA affinity chromatography with the promoter region of the Corynebacterium glutamicum pck gene, encoding phosphoenolpyruvate carboxykinase (PEPCk), led to the isolation of four transcriptional regulators, i.e., RamA, GntR1, GntR2 and IolR. Determination of the PEPCk activity of the deletion mutant...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2013-07-29 | E-GEOD-44812 | biostudies-arrayexpress
UnknownIdentification of 2 Novel Species, Mycobacterium novusgordonae and M. shingordonae.
Not available
S-EPMC11878325 | biostudies-literature
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