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ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018710 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
GenomicsToxoplasma gondii GUY-2004-ABE
Toxoplasma gondii GUY-2004-ABE Genome sequencing
PRJNA170326 | ENA
ProteomicsProximity proteomics of T-tubules
To identify candidate genes unbiasedly, we employed biotinylation-based proximity proteomics of T-tubules in vivo. We generated a transgenic line carrying an Amph construct fused with miniTurbo (mnTb). We expressed either Amph-mnTb or mnTb alone in muscles, and larvae were reared in the presence or ...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2025-11-22 | PXD062543 | JPOST Repository
ProteomicsProximity proteomics of T-tubules using miniTurbo-fused LUBEL
To identify candidate genes unbiasedly, we employed biotinylation-based proximity proteomics of T-tubules in vivo. We generated a transgenic line carrying an LUBEL construct fused with miniTurbo (mnTb). We expressed either LUBEL-mnTb or mnTb alone in muscles, and larvae were reared in the presence o...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2025-11-22 | PXD062634 | JPOST Repository
GenomicsQuadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [ATAC-seq]
Quadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [ATAC-seq]
PRJNA1229423 | ENA
GenomicsQuadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [RNA-seq]
Quadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [RNA-seq]
PRJNA1229426 | ENA
GenomicsQuadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [ATAC-seq]
Genome editing technologies have enabled the clinical development of allogeneic cellular therapies, yet the optimal gene editing modality for multiplex editing of therapeutic T cell product manufacturing remains elusive. In this study, we conducted a comprehensive comparison of CRISPR/Cas9 nuclease ...
ORGANISM(S): Homo sapiens 
2025-04-09 | GSE290620 | GEO
TranscriptomicsQuadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [RNA-seq]
Genome editing technologies have enabled the clinical development of allogeneic cellular therapies, yet the optimal gene editing modality for multiplex editing of therapeutic T cell product manufacturing remains elusive. In this study, we conducted a comprehensive comparison of CRISPR/Cas9 nuclease ...
ORGANISM(S): Homo sapiens 
2025-04-09 | GSE290621 | GEO
GenomicsMouse, Rat, Human
A•T to G•C conversion in mouse and rat embryos via ABE
PRJNA471163 | ENA
UnknownQuadruple adenine base-edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease-engineered T cells.
Not available
S-EPMC12107175 | biostudies-literature
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