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ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
UnknownChanges In County-Level Access To Medications For Opioid Use Disorder After Medicare Coverage Of Methadone Treatment Began.
Not available
S-EPMC11332379 | biostudies-literature
UnknownSurvey Highlights Differences In Medicaid Coverage For Substance Use Treatment And Opioid Use Disorder Medications.
Not available
S-EPMC5304419 | biostudies-literature
UnknownMedicaid Benefits For Addiction Treatment Expanded After Implementation Of The Affordable Care Act.
Not available
S-EPMC6501794 | biostudies-literature
UnknownUnravelling morphoea aetiopathogenesis by next-generation sequencing of paired skin biopsies.
Not available
S-EPMC10366313 | biostudies-literature
ProteomicsDisruption of acetyl group balance in cardiomyocytes augments the mitochondrial acetylproteome without affecting respiratory function or heart susceptibility to pressure overload
Circumstantial evidence links the development of heart failure to perturbations in oxidative metabolism and corresponding shifts in post-translational modifications (PTMs) of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that acetyl-PTMs compromise mitochon...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-02 | PXD013935 | Pride
Lc-msms Mitochondria Mouse Heart Acetylation 
ProteomicsAblation of Sirtuin5 in the postnatal mouse heart results in persistent accumulation of protein succinylation and normal survival in response to chronic pressure overload
Mitochondrial Sirtuin 5 (SIRT5) is an NAD+-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac function and metabolism under stress. Previously, we d...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-16 | PXD008728 | Pride
Protein succinylation Heart function Sirt5 
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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