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ProteomicsStabilization of Interdomain Interactions in G protein α Subunits as a Determinant of Gαi Subtype Signaling Specificity
Highly homologous members of the Gαi family, Gαi1-3, have distinct tissue distributions and physiological functions, yet their biochemical and functional properties are very similar. We recently identified PDZ-RhoGEF (PRG) as a novel Gαi1 effector that is poorly activated by Gαi2. In a proteomic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD050824 | Pride
Heterotrimeric g protein Proximity labeling Mass spectrometry Structure. G protein-coupled receptor Effector coupling Rho gef Domain interactions Alpha subunits 
UnknownStabilization of interdomain interactions in G protein α subunits as a determinant of Gα<sub>i</sub> subtype signaling specificity.
Not available
S-EPMC11066577 | biostudies-literature
UnknownAMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification.
Not available
S-EPMC11838443 | biostudies-literature
UnknownPax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney.
Not available
S-EPMC7269349 | biostudies-literature
UnknownUrinary biomarkers and renal near-infrared spectroscopy predict intensive care unit outcomes after cardiac surgery in infants younger than 6 months of age.
Not available
S-EPMC3653979 | biostudies-literature
ProteomicsA Network G Protein Gai Signaling Partners is Revealed by Proximity Labeling Proteomics and Includes PDZ-RhoGEF
G protein-coupled receptors (GPCRs) that couple to the Gi family of G proteins are key regulators of cell and tissue physiology. Our previous work has revealed new roles for Gαi in regulating the migration of neutrophils and fibrosarcoma cells downstream of activated chemoattractant receptors. We us...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD027905 | Pride
Gαi proteins Proximity labeling Pdz-rhogef Cell-migration Interactome Mass spectrometry Gpcr signaling 
UnknownFunctional Changes to Achilles Tendon and Enthesis in a Mouse Model of an Adolescent Masculine Gender-Affirming Hormone Treatment.
Not available
S-EPMC11195120 | biostudies-literature
UnknownFunctional changes to Achilles tendon and enthesis in an adolescent mouse model of testosterone hormone therapy.
Not available
S-EPMC12105046 | biostudies-literature
UnknownAdhesin Als4112 promotes Candida auris skin colonization through interactions with keratinocytes and extracellular matrix proteins.
Not available
S-EPMC12214902 | biostudies-literature
UnknownMavacamten: a first-in-class myosin inhibitor for obstructive hypertrophic cardiomyopathy.
Not available
S-EPMC10659958 | biostudies-literature
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