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TranscriptomicsMOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix)
In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, how...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-26622 | biostudies-arrayexpress
TranscriptomicsMOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina)
In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, how...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-26625 | biostudies-arrayexpress
UnknownBeta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation.

Background

It has been suggested that beta-blockers may increase mortality in patients with cirrhosis and refractory ascites but the effect of beta-blockers discontinuation or reinitiation has not been examined.

Aims

To compare, in hospitalised patients with cirrhosis and ascites, the...
S-EPMC6016372 | biostudies-literature
UnknownIntestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis.
Chronic alcohol consumption causes increased intestinal permeability and changes in the intestinal microbiota composition, which contribute to the development and progression of alcohol-related liver disease. In this setting, little is known about commensal fungi in the gut. We studied the intestina...
S-EPMC6925657 | biostudies-literature
UnknownSarcopenia HIBA score predicts sarcopenia and mortality in patients on the liver transplant waiting list.
Sarcopenia is a prevalent condition that predicts prognosis in patients awaiting liver transplantation (LT). The gold standard for the diagnosis of sarcopenia is the assessment of the muscular area at L3 with computed tomography (CT) scan (skeletal muscle index [SMI]), but the routine use of CT scan...
S-EPMC9234615 | biostudies-literature
UnknownStratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis.
Endoscopic variceal ligation plus beta-blockers (EVL+BB) is currently recommended for variceal rebleeding prophylaxis, a recommendation that extends to all patients with cirrhosis with previous variceal bleeding irrespective of prognostic stage. Individualizing patient care is relevant, and in publi...
S-EPMC5605404 | biostudies-literature
UnknownRelationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design.

Background

Alcohol-associated hepatitis (AH) is associated with significant mortality. Model for End-Stage Liver Disease (MELD) score is used to predict short-term mortality and aid in treatment decisions. MELD is frequently updated in the course of AH. However, once the most updated MELD is...
S-EPMC12333734 | biostudies-literature
UnknownFull adherence to cirrhosis quality indicators is associated with lower mortality in acute variceal bleeding: Nationwide audit.

Background and aims

Acute variceal bleeding (AVB) is a major complication in patients with cirrhosis. Using a nationwide AVB audit, we performed a nested cohort study to determine whether full adherence to the AVB quality indicator (QI) improves clinical outcomes in patients with cirrhosis a...
S-EPMC11407775 | biostudies-literature
UnknownIntestinal Virome in Patients With Alcoholic Hepatitis.

Background and aims

Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral microbiome (virome) in patients with ALD.

Approac...

S-EPMC8159727 | biostudies-literature
UnknownIntra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation.
Following organ transplantation, lifelong immunosuppressive therapy is required to prevent the host immune system from destroying the allograft. This can cause severe side effects and increased recipient morbidity and mortality. Complete cessation of immunosuppressive drugs has been successfully acc...
S-EPMC3248302 | biostudies-literature
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