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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
MetabolomicsTrapped ion mobilty improves annotation accuracy in LC-HRMS screening applications for exposomics

The widespread use of a large number of chemicals results in a significant exposure of humans and the environment, posing potential risks to human health and ecosystems. To assess the exposure to chemical mixtures, screening applications covering a large number of analytes based on liquid chromat...

2025-10-14 | MTBLS11753 | MetaboLights
TranscriptomicsEffects of sample size on differential gene expression, rank order and prediction accuracy of a gene signature
Gene expression profiles were generated from muscle biopsies from 134 individuals, and differences in expression based on sex were explored. Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reprodu...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-41726 | biostudies-arrayexpress
ProteomicsImpact of Sample Preparation Strategies on The Quantitative Accuracy of Low-Abundance Serum Proteins in Shotgun Proteomics
Serum proteomics plays a crucial role in biomarker discovery and disease research, yet the selection of an optimal sample preparation method remains challenging. Evaluating the accuracy of protein quantitation is of major importance and a vital part of a benchmarking study in proteomics, since clini...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD062785 | Pride
Reproducibility Quantitative accuracy Serum proteomics Depth of coverage 
ProteomicsAsn3 mass accuracy jurkat proteome
The use of internal calibrants (the so called lock mass approach) provides much greater accuracy in mass spectrometry based proteomics. However, the polydimethylcyclosiloxane (PCM) peaks commonly used for this purpose are quite unreliable, leading to missing calibrant peaks in spectra and correspond...
ORGANISM(S): Homo sapiens (Human) 
2013-10-22 | PXD000426 | Pride
Ltq-orbitrap velos Lc-ms/ms Human Mass accuracy 
TranscriptomicsEstimating accuracy of absolute gene expression measurement by RNA-Seq and microarrays with proteomics
Microarrays revolutionized biological research by enabling gene expression comparisons on a transcriptome-wide scale. Microarrays, however, do not estimate absolute expression level accurately. At present, high throughput sequencing is emerging as an alternative methodology for transcriptome studies...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-13744 | biostudies-arrayexpress
GenomicsMEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy
MEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy
PRJNA1474542 | ENA
GenomicsMEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy
MEDUSA: Maintaining Entire DNA Duplexes for Utmost Sequencing Accuracy
PRJNA1474541 | ENA
ProteomicsA Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening
In this study, applying a novel knowledge-based, multi-stage discovery and validation strategy we scaled down from 108 diabetes–associated metabolites to a diagnostic metabolite triplet (Met-T) and it could improve the diagnostic accuracy of prediabetes and diabetes screening.
ORGANISM(S): Homo Sapiens 
2020-11-30 | PXD022801 |
ProteomicsQuantitative accuracy and precision in multiplexed single-cell proteomics.
Multiplexed quantitative mass spectrometry-based proteomics is shaped by numerous opposing propositions. With the emergence of multiplexed single-cell proteomics, studies increasingly present single cell measurements in conjunction with an abundant congruent carrier to improve precursor selection an...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD027912 | Pride
Single-cell proteomics Benchmarking 
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