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ProteomicsCharacterization of lysine acetylation in Toxoplasma gondii proteome lacking acetyl-CoA transporter 1 (AT1).
Acetyl-CoA participates in post-translational modification of proteins, central carbon and lipid metabolism in several cell compartments. In mammals, the acetyl-CoA transporter 1 (AT1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER), enabling the acetylation of prote...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-07-25 | PXD030932 | Pride
Lysine acetylation Toxoplasma gondii Acetyl-coa transporter 1 Nanolc-ms/ms 
ProteomicsN-Acetylation of secreted proteins is widespread in Apicomplexa and independent of acetyl-CoA transporter AT1
Acetyl-CoA critically participates in post-translational modification of proteins, central carbon and lipid metabolism in several compartments of eukaryotic cells. In mammals, the acetyl-CoA transporter 1 (AT1) facilitates the flux of cytosolic acetyl-CoA into the endoplasmic reticulum (ER) enabling...
ORGANISM(S): Toxoplasma gondii Plasmodium berghei 
2022-06-20 | PXD029616 | Pride
Acetyl-coa transporter Toxoplasma gondii Endoplasmic reticulum Acetylome Secretory pathway Plasmodium berghei 
ProteomicsAcetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
The acetyl-CoA transporter, AT-1 (also referred to as SLC33A1), is a key member of the endoplasmic reticulum (ER) acetylation machinery; it transports acetyl-CoA from the cytosol into the ER lumen where it serves as donor of the acetyl group for Nε-lysine acetylation 1,2. Dysfunctional ER acetylatio...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-05 | PXD013736 | Pride
Mouse Suborganelle Liver Lc-ms/ms 
GenomicsAcetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity
Acetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity
PRJNA1423288 | ENA
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Not available
ORGANISM(S): Homo sapiens 
ST001730 | MetabolomicsWorkbench
ProteomicsAcetyl-CoA flux maintains intracellular crosstalk and modulats engagement of the secretory pathway
Nε-lysine acetylation has emerged as a central mechanism to maintain quality control and protein homeostasis within the Endoplasmic Reticulum (ER) and secretory pathway. The ER acetylation machinery includes AT-1/SLC33A1, a membrane transporter that translocates acetyl-CoA from the cytosol to the ER...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019770 | Pride
Mouse Brain Glycoproteomics Lc-ms/ms 
ProteomicsAcetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity
The metabolite acetyl-CoA plays a central role in cellular metabolic homeostasis. As part of the secretory pathway, acetyl-CoA is imported into the endoplasmic reticulum (ER) by a membrane-bound transporter AT-1 (SLC33A1). AT-1 has been linked to peripheral neuropathy (heterozygous mutations), devel...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-11 | PXD075949 | Pride
Metabolism Acetyl-coa Proteomics Neuron Mitochondria 
TranscriptomicsAcetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activity
The metabolite acetyl-CoA plays a central role in cellular metabolic homeostasis. As part of the secretory pathway, acetyl-CoA is imported into the endoplasmic reticulum (ER) by a membrane-bound transporter AT-1 (SLC33A1). AT-1 has been linked to peripheral neuropathy (heterozygous mutations), devel...
ORGANISM(S): Mus musculus 
2026-09-09 | GSE319438 | GEO
UnknownA missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).
Not available
S-EPMC2668077 | biostudies-literature
GenomicsPlasmodium falciparum strain:3D7 and Dd2
KAF156 Resistant Lines Conferring Mutations in Acetyl-CoA Transporter
PRJNA315690 | ENA
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