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Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-co...
ORGANISM(S): Mus musculus 
Regulation of membrane receptors involves management of endocytosis. At the neuromuscular junction, the synapse between skeletal muscle and motoneuron, proper density of the major receptor, the acetylcholine receptor, is of utmost importance for sustaining life in context of mobility. Recent work ha...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-01 | PXD021601 | Pride
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation
This project investigates the role of α7 nicotinic acetylcholine receptor (α7 nAChR) signaling in glioblastoma using the U87MG human glioblastoma cell line. Cells were treated with selective α7 nAChR ligands (10 μM of agonist PNU282987, 1 μM of positive allosteric modulator PNU120596, 1 μM of antago...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD070911 | Pride
α7 Nicotinic Acetylcholine Receptor Regulates Macrophage-Mediated Neuroinflammation in Dry Eye Disease
Short-term depletion of nicotinic acetylcholine receptor subunits in Drosophila enterocytes
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets given their involvement in numerous physiological processes and diseases. Although a cryo-electron microscopy study previously defined the structure of the M3-miniGq complex, the lack of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD042562 | Pride
Apoe3 Enhances Acetylcholine Receptor Clustering via Lrp4
RNA sequencing data describing transcriptional changes in aorta of ApoE-/- mice after alpha 7 nicotinic acetylcholine receptor (α7nAChR) stimulation.
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