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TranscriptomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40064 | biostudies-arrayexpress
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [ChIP-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40063 | biostudies-arrayexpress
ProteomicsThe nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
Domain level interactions between the ISWI remodeler SNF2h and reconstituted mononucleosomes were probed by EDC crosslinking under different biochemical conditions: ADP, ADP-BeFx, ADP-BeFx with LANA peptide added (which binds at the acidic patch). A semi quantitative approach was used to monitor do...
ORGANISM(S): Xenopus Laevis (ncbitaxon:8355) Homo Sapiens (ncbitaxon:9606) 
2018-03-07 | MSV000082136 | MassIVE
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40065 | biostudies-arrayexpress
GenomicsDifferent modes of engagement with the nucleosome acidic patch yield distinct functional outcomes
Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes
PRJNA1378835 | ENA
ProteomicsStructural basis of paralog-specific KDM2A/B nucleosome recognition
The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform for enzymes to dock and orient for nucleosome-targeted activities. In order to define the molecular basis of acidic patch recognition proteome-wide, we performed an amino acid resolution acidic patch interacto...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD032791 | Pride
Nucleosome Demethylase Kdm2b Jmjc Chromatin Acidic patch Kdm2a 
GenomicsDifferent modes of engagement with the nucleosome acidic patch yield distinct functional outcomes
The nucleosome acidic patch is a hub of coordinated engagement by proteins that regulate genomic function. Here we report that S. cerevisiae Dot5 contains an arginine-rich HMGN-like motif that mediates nucleosome acidic patch binding and is required for the cell growth, DNA repair and heterochromati...
ORGANISM(S): Saccharomyces cerevisiae 
2025-12-22 | GSE313255 | GEO
GenomicsThe nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo
We employed MNase-seq and ChIP-seq to determine irregularities in chromatin architecture in mutants of the nucleosome acidic patch. Indeed, the acidic patch mutant showed defects in nucleosome positioning and occupancy at genes with high expression and H2B K123ub levels, linking the acidic patch to ...
ORGANISM(S): Saccharomyces cerevisiae 
2019-06-11 | GSE121543 | GEO
TranscriptomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | GSE40064 | GEO
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [ChIP-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | GSE40063 | GEO
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