Sort   by:  
 Page size 
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
TranscriptomicsTranscription profiling of human HMEC exposed to lactic acidosis and hypoxia
Human Mammalian Epithelial Cells (HMEC) were exposed to different environmental stresses, including hypoxia, lactic acidosis, the combination of hypoxia and lactic acidosis, lactosis , as well as acidosis. We used microarrays to examine the genomic programs of cells incubated under different microen...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-9649 | biostudies-arrayexpress
TranscriptomicsLactic acidosis triggers starvation response with distinct metabolic profiles
[1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for different length of time. We used microarrays to examine the genomic programs of cells incubated under lactic acidosis for different length of time [2] Metabolic profiling: MCF7 cells were exposed to control condition, ...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-19123 | biostudies-arrayexpress
TranscriptomicsThe genomic analysis of the interaction between the lactic acidosis and hypoxia response
Lactic acidosis and hypoxia are two prominent tumor microenvironmental stresses that are both known to exert important influences on gene expression and phenotypes of cancer cells. But very little is known about the cross-talk and interaction between these two stresses. We performed gene expression ...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-29406 | biostudies-arrayexpress
TranscriptomicsAnalysis of the impact of extracellular acidosis on the expression of miRNAs in experimental tumor lines LLC-WRC 256 and R-3327-AT-1 of the rat
Hypoxia has been shown to regulate the miRNA expression in tumors. Since many tumors show a extracellular acidosis the aim of the study was to analyze whether the extracellular pH has an impact on the miRNA expression in experimental tumor cells of the rat. Therefore R3327-AT1 Dunning prostate carci...
ORGANISM(S): Rattus norvegicus 
2023-11-29 | E-MTAB-6600 | biostudies-arrayexpress
TranscriptomicsHUVECs with endogenous or overexpressed GPR4 treated with pH 8.4 (control) or pH 6.4 for 5 h
Acidic tissue microenvironment is commonly found in a variety of pathophysiological conditions. GPR4 is a proton-sensing G protein-coupled receptor that is fully activated by acidic extracellular pH but has lesser activity at the physiological pH 7.4 and minimal activity at more alkaline pH. To dete...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-40060 | biostudies-arrayexpress
ProteomicsIntegrated proteomic and metabolomic analyses of the mitochondrial neurodegenerative disease MELAS
MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes) is a progressive neurodegenerative disease caused by pathogenic mitochondrial DNA variants. The pathogenic mechanism of MELAS remains enigmatic due to the exceptional clinical heterogeneity and the obscure genotype-phenot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-16 | MSV000088237 | MassIVE
TranscriptomicsEffect of Dietary Grain on Rumen Papillae Gene Expression in Holstein Dairy Cows
Four mature, non-lactating dairy cattle were transitioned from a high forage diet (HF; 0% grain) to a high grain diet (HG; 65% grain) that was fed for three weeks. Rumen papillae biopsies were performed during the HF baseline (week 0) and after the first (week 1) and third week (week 3) of the grai...
ORGANISM(S): Bos taurus 
2009-08-28 | E-GEOD-17849 | biostudies-arrayexpress
ProteomicsAcidosis attenuates the hypoxic stabilization of HIF-1α by activating its lysosomal degradation
The adaptive responses to oxygen depletion orchestrated by hypoxia-inducible factors (HIFs) produce profound effects on multiple pathways. A canonical metabolic response is enhanced fermentation, but this can generate an unfavorably acidic environment under poor capillary perfusion. It is unclear ho...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD062474 | Pride
Acidosis Colorectal cancer Hypoxia inducible factor Hypoxia Tumour microenvironment Sw1222 
ProteomicsMCF7 SILAC Comparison of Protein Expression for Acidosis Biomarkers
MCF7 cells were grown in culture under low pH and physiological pH conditions in order to generate candidate biomarkers for tumor acidosis. SILAC was used to enable comparison of protein expression levels using relative quantification. Two biological replicates were prepared using "label flipping,...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD002860 | Pride
Breast cancer Silac Mcf7 cells Acidosis 
Sort   by:  
 Page size