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MetabolomicsMetabolic responses of rice cultivars with different tolerance to combined heat and drought stress under field conditions
Rice is susceptible to both heat and drought stress, in particular during flowering and grain filling, when both grain yield and quality may be severely compromised. However, under field conditions, these two stresses rarely occur separately. Under well-watered conditions, plants avoid heat stress b...
2019-04-25 | MTBLS801 | MetaboLights
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsMolecular Basis Underlying Common Cutworm Resistance of the Primitive Soybean Landrace Peking

The common cutworm (CCW; Spodoptera litura) is one of the major insect pests of soybean in Asia and Oceania. Although quantitative trail loci related to CCW resistance have been introduced into leading soybean cultivars, these do not exhibit sufficient resistance against CCW. Thus, under...

2020-11-06 | MTBLS1960 | MetaboLights
MetabolomicsParabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces ...
2023-11-01 | MTBLS7943 | MetaboLights
TranscriptomicsHeat shock: genomic run-on (GRO) analysis
This SuperSeries is composed of the following subset Series: GSE24483: TR heat-shock GSE24484: RA heat-shock Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-19 | E-GEOD-24488 | biostudies-arrayexpress
TranscriptomicsDissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays
Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination of targeted mutagenesis and whole-genome expression profiling was used to ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-03-07 | E-BUGS-2 | biostudies-arrayexpress
TranscriptomicsTR heat-shock
Within a GRO experiment, samples for Transcription rate (TR) analysis were taken at 0, 4, 11, 16, 26 and 40 minutes after heat stress (from 25ºC to 37ºC) and subjected to run-on. Analysis was done in filters also used for RA analysis of aliquots from the same cultures. The analysis includes 3 repeat...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-19 | E-GEOD-24483 | biostudies-arrayexpress
TranscriptomicsRA heat-shock
Within a GRO experiment, samples for mRNA amount (RA) were taken at 0, 4, 11, 16, 26 and 40 minutes after heat stress (from 25ºC to 37ºC). Analysis was done in filters also used for Transcription rate (TR) analysis of aliquots from the same cultures. The analysis includes 3 repeats of stress treatme...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-19 | E-GEOD-24484 | biostudies-arrayexpress
ProteomicsHeat and pressure resistance relates to protein folding and aggregation
The locus of heat resistance (LHR) confers extreme heat resistance in E. coli. This study explored the role of the LHR in pressure resistance of E. coli, as well as its relationship with protein folding and aggregation in vivo. The role of LHR was investigated in E. coli MG1655 expressing a ibpA-yfp...
ORGANISM(S): Escherichia coli 
2020-01-27 | PXD011023 | Pride
Food preservation Escherichia coli Pressure resistance Inclusion bodies 
TranscriptomicsTranscriptional response to the HSP70 inhibitor MAL3-101 in parental rhabdomyosarcoma cells and isogenic acquired-resistance lines.
We demonstrate that inhibition of HSP70 with MAL3-101 induces activation of the unfolded protein response, and that cells with acquired resistance upregulate a cytosolic HSP70 at the level of mRNA. Whole transcriptome sequencing was undertaken of parental or acquired-resistance RMS13 cells treated w...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-GEOD-80525 | biostudies-arrayexpress
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