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ProteomicsProteome Analysis of Actinoplanes sp. SE50/110
The acarviose metabolite acarbose is an a glucosidase inhibitor produced by Actinoplanes sp. SE50/110. It is medically important because it is used in the treatment of type 2 diabetes. In this work a comprehensive proteome analysis of Actinoplanes sp. SE50/110 was carried out. The associated txt and...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2015-10-21 | PXD001497 | Pride
Actinoplanes sp. se50/110 
ProteomicsThe expression of the acarbose biosynthetic gene cluster of Actinoplanes sp. SE50/110 is dependent on the growth phase
Actinoplanes sp. SE50/110 produces the diabetes type II drug acarbose only during the growth phase and not in the stationary phase. This correlation between the course of the cell growth and the biosynthesis could be due to a decreasing expression of the acarbose biosynthesis genes until the station...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2021-09-09 | PXD017973 | Pride
Acarbose Proteomics Co-regulation Transcriptomics Actinoplanes sp. se50/110 Expression dynamics 
TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
GenomicsActinoplanes sp. SE50/110
Actinoplanes sp. SE50/110 Genome sequencing
PRJNA76835 | ENA
TranscriptomicsComparative microarrays of Actinoplanes sp. SE50/110 ΔacrA with the Actinoplanes sp. SE50/110 wildtype
In order to characterize the transcriptional regulator AcrA, comparative genome wide transcriptome analyses were conducted. Therefore, the wild type Actinoplanes sp. SE50/110 and the mutant ΔacrA were each cultivated in triplicates in minimal medium supplemented with maltose or glucose as single car...
ORGANISM(S): Actinoplanes sp. SE50/110 
2017-06-30 | E-MTAB-5459 | biostudies-arrayexpress
TranscriptomicsComparative microarrays of Actinoplanes sp. SE50/110 ΔmalT with the Actinoplanes sp. SE50/110 wildtype
In order to characterize the transcriptional regulator MalT, comparative genome wide transcriptome analyses were conducted. Therefore, the wild type Actinoplanes sp. SE50/110 and the mutant ΔmalT were each cultivated in triplicates in minimal medium supplemented with maltose or glucose as single car...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-04-01 | E-MTAB-8815 | biostudies-arrayexpress
TranscriptomicsThe transcription dynamics in Actinoplanes sp. SE50/110 during growth.
Actinoplanes sp. SE50/110 was grown in three biological replicates in fermenter cultivation in maltose minimal medium. The transcriptomic changes during growth were monitored by sampling every 24 h. RNA-seq of all 7 replicates and a pooled RNA sample of all time points of each fermenter was performe...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-04-01 | E-MTAB-8857 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA of Actinoplanes sp. SE50/110 to analyze gene function of alternative sigma factor gene ACSP50_0507
Cultivation in maltose minimal media and sampling at different time point (t2 = 96h; t3=118h; t4 = 142h; t5 = 166h) of Actinoplanes sp. SE50/110 empty vector control and Actinoplanes sp. SE50/110 ACSP50_0507 overxepression mutant. RNAseq material and methods
ORGANISM(S): Actinoplanes sp. SE50/110 
2024-07-22 | E-MTAB-13644 | biostudies-arrayexpress
GenomicsActinoplanes sp. SE50/110
Time-course transcriptome data during the whole process of acarbose fermentation of Actinoplanes sp. SE50/110
PRJNA1372424 | ENA
TranscriptomicsWhole track RNAseq of two vector integration mutants of Actinoplanes sp. SE50/110 (pSET152::acbB and pSETT4::acbB).
The whole coding RNA of Actinoplanes sp. SE50/110 mutants containing two different integrative vectors (pSET152::acbB and pSETT4::acbB) were sequenced. Both vectors are integrated via a phiC31 integrase (Bierman et al. 1992) into the genetic locus ACSP50_6589 (former: acpl_6602) (Gren et al. 2016). ...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-05-30 | E-MTAB-8967 | biostudies-arrayexpress
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