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MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
MetabolomicsApoptosis-inducing effects of aqueous extract of Eleutherococcus senticosus on non-small cell lung cancer cell proliferation

Non-small cell lung cancer is a malignant tumor with high morbidity and mortality worldwide. Eleutherococcus senticosus can induce apoptosis in non-small cell lung cancer cells, but the mechanism remains unclear. This study aimed to elucidate the role of Eleutherococcus senticosus in inducing apo...

2025-05-12 | MTBLS10545 | MetaboLights
GenomicsPD-1 Protects Bystander-Activated T Cells from Activation-Induced Cell Death
PD-1 Protects Bystander-Activated T Cells from Activation-Induced Cell Death
PRJNA820849 | ENA
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
ProteomicsThe ribotoxic stress response drives UV-mediated cell death.
Supporting raw MS data for paper (doi: 10.1016/j.cell.2024.05.018) by Sinha N.K. et al, titled "The ribotoxic stress response drives UV-mediated cell death". Index of MS files and labels Table S1 - HaCaT Timecourse. 1-1 - Proteome (AO3604-3627 | Unimod:35; 2016; 4 | 126 -UT_01; 127n - UT_02; 12...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-25 | MSV000092521 | MassIVE
GenomicsSedanolide ameliorates hydrogen peroxide-induced apoptotic cell death via activation of KEAP1-NRF2 pathway
Sedanolide ameliorates hydrogen peroxide-induced apoptotic cell death via activation of KEAP1-NRF2 pathway
PRJNA1028497 | ENA
UnknownThe linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
Not available
S-EPMC5412822 | biostudies-literature
TranscriptomicsTranscription profiling of E. coli cells during cell death programmed by a restriction-modification system
Genetically programmed deaths play important roles in the biology of unicellular prokaryotic cells. Some gene complexes force their maintenance on the host bacterial cells by killing cells that have lost them. This form of programmed death called post-segregational killing or genetic addiction is br...
ORGANISM(S): Escherichia coli 
2009-07-04 | E-GEOD-7326 | biostudies-arrayexpress
TranscriptomicsEither Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis
Stable activation of the WNT signaling effector beta-catenin (CTNNB1(ex3) in ovarian granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life. Loss of the tumor suppressor gene Pten accelerates GCT formation in the CT...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-27656 | biostudies-arrayexpress
TranscriptomicsMechanism of cell death induced by saporin
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-42138 | biostudies-arrayexpress
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