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ProteomicsValidation and application of a novel KLK6 activity based probe (IMP2352)
Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of signaling cascades and cleavage of extracellular matrix proteins, and the kallikrei...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD035111 | Pride
Abpp Klk Activity-based probe Kallikrein-related peptidase N-terminomics 
ProteomicsActivity based proteome profiling of serum serine hydrolases: application in pediatric abusive head trauma
Purpose: Traumatic brain injury (TBI), including pediatric abusive head trauma (AHT), is the leading cause of death and disability in children and young adults worldwide. The current understanding of trauma-induced molecular changes in the brain of human subjects with intracranial haemorrhage (ICH) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-26 | PXD057319 | Pride
Human Serum Activity based proteome profilling 
ProteomicsA General Approach for Activity-based Protein Profiling of Oxidoreductases with Redox-differentiated Diarylhalonium Warheads
Activity-based protein profiling (ABPP) is a unique proteomic tool for measuring the activity of enzymes in their cellular context, which has been well established for enzyme classes exhibiting a characteristic nucleophilic residue (e.g. hydrolases). In contrast, the enzyme class of oxidoreductases ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD043873 | Pride
Oxidoreductase probe Mouse liver; Activity-based protein profiling 
ProteomicsABPP-HT - high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context
The potency and selectivity of a small molecule inhibitor are key parameters to assess during the early stages of drug discovery. In particular, it is very informative for characterizing compounds in a relevant cellular context in order to reveal potential off-target effects and drug efficacy. Activ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-02-24 | PXD023036 | Pride
Drug discovery Pharmacology Activitomics Deubiquitylating enzymes Ubiquitin Automation Activity-based probes 
UnknownProspective Application of Activity-Based Proteomic Profiling in Vision Research-Potential Unique Insights into Ocular Protease Biology and Pathology.
Not available
S-EPMC6720450 | biostudies-literature
ProteomicsDruggable Serine Proteases of Leishmania by Activity‐Based Protein Profiling
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of action, are urgently needed to treat the disease. Alt...
ORGANISM(S): Leishmania mexicana 
2022-07-04 | PXD033616 | Pride
Activity-based protein profiling Leishmania Serine protease 
ProteomicsActivity-based proteomic profiling (ABPP) employing a serine hydrolase-directed probe to identify changes in activity profiles of lipid hydrolase in lung tumors
Lung tumors, as well as normal tumor-adjacent (NTA) tissue of non-small cell lung cancer (NSCLC) patients, were collected and subjected to labeling with a serine hydrolase-directed activity-based probe (ABP) immediately after excision. Labeling with the serine hydrolase-directed ABP allows for the d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD046934 | Pride
Abpp Lipid hydrolysis Serine hydrolase Nsclc Lipid hydrolase Lung tumor Activity-based proteomic profiling Lipase 
ProteomicsCIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-based Probe Profiling (ABPP) Data
Activity-based Protein Profiling (ABPP) is a powerful chemo-proteomic method to study proteins’ activity, modifications and interactions in a high-throughput manner. In ABPP experiments, accurate quantification is crucial to determine the extent of probe labeling at the level of either target protei...
ORGANISM(S): Homo Sapiens 
2021-03-16 | PXD024754 |
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
ProteomicsActivity-Guided Proteomic Profiling of Proteasomes
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD045051 | Pride
Activity-guided profilling Proteasome 
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