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MetabolomicsFisetin ameliorates acute colitis in mice via gut microbiota associated linoleic acid metabolism to regulate Th17/Treg balance

This study investigated the therapeutic effects of FST on colitis in mice by exploring its impact on the gut microbiota, metabolites, and immune response. The results show FST alleviated colitis in mice, including mitigated weight loss, improved colon length shortening, and reduced mRNA expressi...

2025-12-03 | MTBLS13284 | MetaboLights
MetabolomicsUntargeted LC–MS serum metabolomics in a colitis mouse model treated with the microbiota-regulating nanomedicine MRA@RP

This study applies untargeted liquid chromatography–mass spectrometry (LC–MS)–based serum metabolomics to characterize metabolic alterations in a dextran sulfate sodium–induced colitis mouse model and to evaluate the therapeutic effects of the microbiota-regulating nanomedicine MRA_RP. Serum samp...

2025-11-22 | MTBLS13367 | MetaboLights
MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
MetabolomicsD-lactate-free probiotic treatment in colitis
Effect of the D-lactate free bacteria in DSS-induced colitis mouse model
2026-10-09 | MTBLS15974 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of the cecal contents in gliadin-induced colitis mice

Background: Gliadin, a key dietary antigen in celiac disease and intestinal inflammation, has unclear effects on the local metabolic microenvironment of the gut under colitic conditions. Objective: This study aimed to systematically characterize the metabolic alterations in cecal contents of glia...

2026-08-19 | MTBLS15178 | MetaboLights
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
MetabolomicsLily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights
MetabolomicsFecal short-chain fatty acids in DSS-induced colitis mice treated with a D-lactate-free probiotic
Targeted GC-MS quantification of short- and branched-chain fatty acids in feces of C57BL/6J (B6J-UniBe) mice with acute dextran sulfate sodium (DSS)-induced colitis. Mice received the D-lactate-free probiotic consortium Pro4-50 by daily oral gavage either from the start of the experiment (Pre, n=10)...
2026-10-08 | MTBLS15952 | MetaboLights
TranscriptomicsColonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice
The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphat...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
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