Sort   by:  
 Page size 
MetabolomicsLactobacillus johnsonii-derived oxindole protects acute lung injury by reducing CXCL13
Gut microbiota is altered in mice with acute lung injury (ALI). Supplementation with Lactobacillus johnsonii, which is deficient in it, improved ALI in mice, and we elucidated the underlying mechanisms of the improvement by metabolomics.
2026-02-12 | MTBLS11438 | MetaboLights
MetabolomicsMetabolomic analyses in sepsis-associated acute lung injury rats

Sepsis-associated acute lung injury (SALI) is a life-threatening pulmonary complication triggered by sepsis, which carries a notably high mortality rate. We constructed a rat model of SALI and administered Xuanbai Chengqi Decoction (XCD) as treatment, after which untargeted serum metabolomics ana...

2026-09-29 | MTBLS15292 | MetaboLights
MetabolomicsCombined analysis of cecal microbiota and metabolomics reveals the intervention mechanism of Dayuan Yin in acute lung injury

The ancient Chinese medicinal formula, Dayuan Yin (DYY), has a long history of use in treating respiratory ailments and shown to be effective in treating acute infectious diseases. This study aims to explore how DYY may impact intestinal flora and metabolites induced by acute lung injury (ALI). A...

2024-09-20 | MTBLS10741 | MetaboLights
MetabolomicsAtractylodin targets ASAH3L to regulate galactose metabolism and thereby modulates the HIF-1 signaling pathway for the treatment of acute lung injury

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

2024-07-23 | MTBLS9948 | MetaboLights
MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
Background: Artemisia argyi is a traditional medicinal herb with established anti-inflammatory and immunomodulatory properties. Its aqueous extract (AEAA), enriched in water-soluble bioactive constituents, exhibits favorable safety and bioavailability; however, its potential protective effects again...
2026-03-27 | MTBLS14160 | MetaboLights
MetabolomicsAqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression
his study investigated the metabolic alterations in colonic contents associated with aqueous extract of Artemisia argyi (AEAA) intervention in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. Male C57BL/6 mice were randomly divided into control, LPS, and AEAA treatment groups ...
2026-03-27 | MTBLS14155 | MetaboLights
MetabolomicsProphylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Although itaconate demonstrates anti-inflammatory and antimicrobial properties as an immunomodulatory metabolite, the therapeutic potential and mechanistic basis of vaccine-induced or prophylactic itaconate administration in COVID-19 intervention remains underexplored. Our studies reveal that int...

2025-08-06 | MTBLS12827 | MetaboLights
MetabolomicsIntegrated pharmacological and metabolomic characterization of a polysaccharide-enriched fraction from Qingfei-Paidu Decoction for protection against acute lung injury in mice
The formula of Qingfei-Paidu Decoction was separated into a polysaccharide-enriched fraction (PSC) and an ethanol-soluble small-molecule fraction (EtOH), whose biological activities were systematically compared under equivalent crude drug conditions using an LPS-induced ALI mouse model and macrophag...
2026-10-05 | MTBLS15898 | MetaboLights
ProteomicsProteomic analysis of lung tissues in an oleic acid (OA)-induced acute lung injury model rats
Data analyzed proteins extracted from lung tissue samples from OA-induced acute lung injury model rats. Samples were collected at 0 (pretreatment), 3, 6, 24, 48, 96 h after OA administration. Whole tissue extracts were prepared from three individuals and analyzed using the DIA-MS method.
ORGANISM(S): Cellular Organisms 
2025-03-14 | PXD057386 | JPOST Repository
MetabolomicsAnalysis of human urine reveals metabolic changes related to the development of acute kidney injury following cardiac surgery
In an effort to identify novel biomarkers capable of predicting the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB) use, urine specimens were collected before and at 4 and 24 hours after surgery from 106 patients and analyzed by means of nuclear magne...
2012-10-21 | MTBLS24 | MetaboLights
Sort   by:  
 Page size