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TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
MetabolomicsNon-redundant cardiolipin synthase family proteins shape lipid composition and stress resilience in Bacteroides fragilis

Gut-resident bacteria must withstand membrane-disrupting stresses such as bile acids to persist in the intestinal environment. The Bacteroidota are a dominant phylum of the human gut microbiota. However, the genes responsible for synthesis of membrane lipids in this phylum remain relatively uncha...

2026-10-06 | MTBLS11891 | MetaboLights
ProteomicsProfiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
National screening programs use dried blood specimens to detect abnormal metabolism or aberrant protein function in infants shortly after birth, thus identifying disorders that are not clinically evident in the newborn period. Gut microbiota metabolites and immunological acute phase proteins are cap...
ORGANISM(S): Homo Sapiens 
PXD027606 | panorama
ProteomicsMultiplex assay for quantification of acute phase proteins and immunoglobulin A in dried blood spots
Inflammation is the first line defense mechanism against infection, tissue damage or cancer development. However, inappropriate inflammatory response may also trigger diseases. The quantification of inflammatory proteins is essential to distinguish between harmful and beneficial immune response. Cur...
ORGANISM(S): Homo Sapiens 
2018-12-05 | PXD011944 | panorama
ProteomicsSite-specific O-Glycosylation Analysis of Human Blood Plasma Proteins
Here, we report on the site-specific O-glycosylation analysis of human blood plasma glycoproteins. To this end pooled human blood plasma of healthy donors was digested non-specifically using Protein-ase K, followed by a precipitation step, as well as a glycopeptide enrichment and fractionation step ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-06-05 | MSV000079141 | MassIVE
ProteomicsProteomic analysis of septic renal acute phase response
Sepsis-induced acute kidney injury (AKI) is the most common form of AKI with poor outcomes. Renal proteomic analysis after bacterial lipopolysaccharide (LPS) administration revealed that the local renal acute phase reaction (APR) is one of the strongest responses of the kidney during septic AKI in m...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-08 | PXD014664 | Pride
Lipopolysaccharide Mouse Sepsis Kidney Lc-ms/ms 
ProteomicsSERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD050496 | Pride
Biomarkers Malaria Acute resipratory distress syndrome Proteomics 
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-05-27 | GSE22009 | GEO
TranscriptomicsGp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways
Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure tissue specific responses after proinflammatory stimulus with IL-6 across different time points. We ...
ORGANISM(S): Mus musculus 
2010-11-13 | E-GEOD-25278 | biostudies-arrayexpress
GenomicsTranscriptome profiling of the hepatic acute-phase response in LPS-treated dHepaRG cells.
Transcriptome profiling of the hepatic acute-phase response in LPS-treated dHepaRG cells.
PRJNA958246 | ENA
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