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MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
TranscriptomicsExpression data from non-demented controls (NDCs) and Alzheimer's disease (AD) patients
AD is the leading cause of dementia in the elderly. However, disease etiology is still practically unknown. To gain insight into the molecular mechanisms underlying this disease we used the Affymetrix exon arrays to profile the alternative splicing landscape of human entorhinal cortex samples from A...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-26972 | biostudies-arrayexpress
TranscriptomicsGene expression data from temporal cortex of young adult, old and AD-like Microcebus murinus
Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease (AD). However, the molecular events occurring during brain aging are extremely complex and still largely unknown. For a better understanding of these age-associated modifications, animal models as close as po...
ORGANISM(S): Microcebus murinus 
2011-04-01 | E-GEOD-21779 | biostudies-arrayexpress
ProteomicsA Mass Spectrometry Approach Reveals a New Toxic Role For Alzheimer’s Disease A? Peptide: SPLICEOSOME IMPAIRMENT
Alzheimer’s disease is the most common form of dementia, and its prevalence increases exponentially with age. The patients affected gradually lose cognitive function, control over their sense of orientation, their emotions, and other aspects of behavior. Thirty-five million people are now considered...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-27 | MSV000081021 | MassIVE
TranscriptomicsAlzheimer's disease and the normal aged brain (steph-affy-human-433773)
Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnos...
ORGANISM(S): Homo sapiens 
2006-07-10 | E-GEOD-5281 | biostudies-arrayexpress
TranscriptomicsEarly immunologic events at the tick-host interface
Ixodes species ticks are competent vectors of tick-borne viruses including tick-borne encephalitis and Powassan encephalitis.  Tick saliva has been shown to facilitate and enhance viral infection.  This likely occurs by saliva-mediated modulation of host responses into patterns favorable for viral i...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-39100 | biostudies-arrayexpress
ProteomicsHippocampal disruptions of synaptic and astrocyte metabolism during early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, suggesting an important metabolic component of early AD path...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-09 | PXD025240 | Pride
Synaptosomes Hippocampus Ad Brain energy metabolism Seahorse Mitochondria Glucose Cerebral cortex 
ProteomicsA Mass Spectrometry Approach Reveals a New Toxic Role For Alzheimer’s Disease Aβ Peptide: SPLICEOSOME IMPAIRMENT
Alzheimer’s disease is the most common form of dementia, and its prevalence increases exponentially with age. The patients affected gradually lose cognitive function, control over their sense of orientation, their emotions, and other aspects of behavior. Thirty-five million people are now considered...
ORGANISM(S): Homo sapiens (Human) 
2017-02-06 | PXD002842 | Pride
Aβ42 Alzheimer’s disease Human Orbitrap Splicing Ad early events 
UnknownProdromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.
Not available
S-EPMC7278916 | biostudies-literature
TranscriptomicsSingle-cell sequencing of cerebral organoids with familial Alzheimer’s disease (AD) mutation in PSEN1 and non-demented control
We set up a 3D model based on iPSCs derived from patients with familial forms of Alzheimer’s disease (AD) and healthy non-demented control. We created cerebral organoids (COs), verified their ability to mimic AD in vitro, and used it to explore early events and the progression of AD pathogenesis. Ou...
ORGANISM(S): Homo sapiens 
2022-07-01 | E-MTAB-11438 | biostudies-arrayexpress
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