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ProteomicsA red blood cell-based antigen delivery system to facilitate T cell epitope presentation to induce peripheral tolerance to ADAMTS13 in immune-mediated TTP
Aims Leveraging the tolerogenic nature of their natural clearance pathway, we aim to exploit red blood cells (RBCs) as an antigen delivery system to achieve persistent exposure to ADAMTS13-derived peptides, promoting antigen-specific attenuation of autoreactive CD4+ T cells and induction of regulato...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD064980 | Pride
Adamts13 Ittp Immunopeptidomics Antigen presentation 
TranscriptomicsGenome wide expression in ADAMTS13-deficient thrombotic thrombocytopenic purpura TTP
This study sought correlates of relapse tendency in TTP by examining gene expression profiles in peripheral blood leukocytes from patients with acquired ADAMTS13-deficient TTP in remission and matched healthy controls for global gene expression and autoantibodies. Total RNA was isolated from PAXgene...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-36418 | biostudies-arrayexpress
TranscriptomicsGenome wide expression in ADAMTS13-deficient thrombotic thrombocytopenic purpura TTP
This study sought correlates of relapse tendency in TTP by examining gene expression profiles in peripheral blood leukocytes from patients with acquired ADAMTS13-deficient TTP in remission and matched healthy controls for global gene expression and autoantibodies.
ORGANISM(S): Homo sapiens 
2013-03-07 | GSE36418 | GEO
UnknownMechanisms of ADAMTS13 regulation.
Not available
S-EPMC9826392 | biostudies-literature
UnknownADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice.
Not available
S-EPMC5782810 | biostudies-literature
UnknownAnti-ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune-Mediated TTP.
Not available
S-EPMC12417756 | biostudies-literature
UnknownSystemic antithrombotic effects of ADAMTS13.
Not available
S-EPMC2118248 | biostudies-literature
UnknownCorrection of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.
Not available
S-EPMC2613173 | biostudies-literature
UnknownGenetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels.
Not available
S-EPMC5728318 | biostudies-literature
UnknownReduced ADAMTS13 activity is associated with an ADAMTS13 SNP, fever and microparticles in a malaria-like model.
Not available
S-EPMC3882324 | biostudies-literature
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