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ProteomicsDegradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate
ADAMTS9 and ADAMTS20 are homologous secreted proteases implicated in ECM proteolysis and ciliogenesis, but few relevant substrates of these proteases are currently known. Quantitative N-terminomics comparison of RPE-1 cells lacking ADAMTS9 with parental RPE-1 cells identified transmembrane protease ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036612 | Pride
Mt1-mmp Rpe-1 cells Ciliogenesis Adamts9 Adamts20 Mmp14 Extracellular matrix 
GenomicsAdamts9 Is Required for Development of Primary Ovarian Follicles and Maintenance of Female Sex in Zebrafish
Adamts9 Is Required for Development of Primary Ovarian Follicles and Maintenance of Female Sex in Zebrafish
PRJNA1101048 | ENA
TranscriptomicsAdamts9 Is Required for Development of Primary Ovarian Follicles and Maintenance of Female Sex in Zebrafish
Previous studies have suggested that adamts9 (a disintegrin and metalloprotease with thrombospondin type-1 motifs, member 9), an extracellular matrix (ECM) metalloprotease, participates in primordial germ cell (PGC) migration and necessary for female fertility. In this study, we found that adamts9 k...
ORGANISM(S): Danio rerio 
2024-04-16 | GSE264143 | GEO
UnknownMutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy.
Not available
S-EPMC6323550 | biostudies-literature
Methylation profilingADAMTS9-AS2 acts as an epigenetic brake to constrain DNMT3B-mediated CADM2 silencing in esophageal squamous cell carcinoma metastasis
Introduction: Metastatic recurrence drives dismal survival in esophageal squamous cell carcinoma (ESCC), yet epigenetic mechanisms underlying metastasis remain poorly defined. While DNMT1 and DNMT3A contribute to ESCC pathogenesis, DNMT3B’s role is enigmatic despite frequent dysregulation. Methods: ...
ORGANISM(S): Homo sapiens 
2026-03-25 | GSE322956 | GEO
GenomicsUpregulation of lncRNA ADAMTS9-AS2 promotes salivary adenoid cystic carcinoma (SACC) metastasis via miR-143-3p-mediated regulation of PI3K/Akt and MEK/Erk signaling
Neurotropic infiltrative growth and distant metastasis are the main causes of death in salivary adenoid cystic carcinoma (SACC) patients. Long noncoding RNAs (lncRNAs) are involved in many human neoplasms, however their potential roles in SACC are unclear. In our study, we found that ADAMTS9-AS2 was...
ORGANISM(S): Homo sapiens 
2018-07-25 | GSE117575 | GEO
UnknownADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations.
Not available
S-EPMC6385758 | biostudies-literature
UnknownBioinformatics Analysis and Functional Verification of ADAMTS9-AS1/AS2 in Lung Adenocarcinoma.
Not available
S-EPMC8358405 | biostudies-literature
UnknownDelay in primordial germ cell migration in adamts9 knockout zebrafish.
Not available
S-EPMC8058341 | biostudies-literature
UnknownCharacterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5.
Not available
S-EPMC12226136 | biostudies-literature
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