Sort   by:  
 Page size 
TranscriptomicsProteolytic inactivation of the autoinhibitory prodomain is essential for the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP)
Invasive cancers employ pericellular proteolysis to breach the extracellular matrix and basement membrane barriers and invade the surrounding tissue. Pro-invasive, pro-tumorigenic MT1-MMP is the primary mediator of proteolytic events on the cancer cell surface. Cellular MT1-MMP is synthesized as a l...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28655 | biostudies-arrayexpress
ProteomicsInhibition of ß1 integrin induces its association with MT1-MMP and decreases MT1- MMP internalization and cellular invasiveness
Integrin signaling plays a fundamental role in the establishment of focal adhesions and the subsequent formation of invadopodia in malignant cancer cells. Invadopodia facilitate localized adhesion and degradation of the extracellular matrix (ECM), which promote tumour cell invasion and metastasis. D...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD024000 | Pride
Extracellular matrix  integrin  mt1-mmp  invadopodia 
TranscriptomicsGenome-wide analysis of MCF-7 cells expressing or not MMP-14 (MT1-MMP) growing in monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (VEC) or human MMP-14 cDNA (MT1) in monolayer growth conditions. MCF-7 cel...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-64320 | biostudies-arrayexpress
ProteomicsCancer Cell Extravasation Requires iPlectin Mediated Choreography of MT1-MMP at Invadopodia
Cancer cell extravasation is a key step of the metastatic cascade and an attractive therapeutic opportunity. Early steps in cancer cell extravasation require formation of tentacle-like protrusions called invadopodia that physically breach the endothelial barrier and degrade extracellular matrix (EC...
ORGANISM(S): Homo sapiens (Human) 
2025-03-28 | PXD039276 | Pride
Invadopodia Cancer Protein-protein interactions 
TranscriptomicsRNAi profiling of human fibrosarcoma cell line knocked down for MT1-MMP
To define the role of MT1-MMP in the tumor progression, we suppressed its expression in human fibrosarcoma cell line, HT1080, using RNAi technique. The gene expression pattern was then compared betweent the two experimental cell groups with contrasting MT1-MMP expression level.
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-1774 | biostudies-arrayexpress
GenomicsExpression array of Mt1-mmp+/+ and Mt1-mmp-/- mouse macrophages in response to LPS or IL-4
Expression array of Mt1-mmp+/+ and Mt1-mmp-/- mouse macrophages in response to LPS or IL-4
PRJNA506441 | ENA
TranscriptomicsComparison of gene expression in mouse placentas with different combination of MT1-MMP and MT2-MMP alleles
MT1-MMP and MT2-MMP double deficiency in mice leads to development of a placental defect resulting in embryonic death after E10.5. The protein substrate for these two proteases in placenta is unknown, which poses an obstacle in uncovering of molecular mechanism behind the observed placental defect. ...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-18604 | biostudies-arrayexpress
ProteomicsDegradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate
ADAMTS9 and ADAMTS20 are homologous secreted proteases implicated in ECM proteolysis and ciliogenesis, but few relevant substrates of these proteases are currently known. Quantitative N-terminomics comparison of RPE-1 cells lacking ADAMTS9 with parental RPE-1 cells identified transmembrane protease ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036612 | Pride
Mt1-mmp Rpe-1 cells Ciliogenesis Adamts9 Adamts20 Mmp14 Extracellular matrix 
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
TranscriptomicsMT1-MMP induces malignant transformation in Mammary cells
Expression of the MT1-MMP gene induces a significant upregulation of of oncogenes and tumorignenic genes in 184B5-MT1 cells. Keywords: Genetic modification
ORGANISM(S): Homo sapiens 
2006-06-21 | GSE5095 | GEO
Sort   by:  
 Page size