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ProteomicsProteomics of Brain Proteome Revealed Altered Mitochondrial Function in Alzheimer Disease
A discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics was used to profiled the mitochondrial proteome in human brain tissues of healthy and AD individuals.
ORGANISM(S): Homo sapiens (Human) 
2019-02-01 | PXD012203 | Pride
Human brain 
ProteomicsOxidative Stress Biomarker of Type 2 Diabetes Mellitus
In this project, using discovery-based mass spectrometry approach and adopting data-dependent LC-MS/MS, we detected and identified modified peptides in complex clinical plasma samples and developed first-level biomarker verification strategy. Further, using liquid chromatography-multiple reaction mo...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012667 | Pride
Human plasma 
ProteomicsPROTEOLYTIC SIGNATURES OF THROMBIN-DERIVED PEPTIDES by LC-MS/MS
We hypothesized that the peptide profile could reflect the action of different proteases present in wounds. However, the complexity of such peptide systems, and lack of efficient analytic tools, until recently has hampered their clinical exploitation and use. In this project, we set out to define cl...
ORGANISM(S): Homo sapiens (Human) 
2017-10-20 | PXD006992 | Pride
Lc-ms/ms Antimicrobial peptide 
ProteomicsHuman aqueous humor of Primary open angle glaucoma LC-MS/MS
The main objective of this study was to adopt discovery based approach and define quantitative expression of human AH samples of glaucoma (N= 5) and non-glaucoma subjects (N=5) by using a state-of-the-art high performance liquid chromatography coupled mass spectrometry, to establish the relative reg...
ORGANISM(S): Homo sapiens (Human) 
2018-06-15 | PXD007624 | Pride
Primary open angle glaucoma 
ProteomicsHuman hair shaft LC-MS/MS - Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins
The aim of this work was to define the hair proteome after extractions with both detergent and detergent-free buffers using highly sensitive proteomics technologies based on mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-01-30 | PXD007224 | Pride
Human scalp hair shaft 
ProteomicsHuman Brain LC-MS/MS
Brian Protein Deamidation Associated with Amyloidosis Revealed by Soluble and Amyloidal Brian Proteome Profiling
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080692 | MassIVE
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