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TranscriptomicsTranscription profiling of human hMADS cells during adipocyte and osteoblast differentiation
human adipocyte and osteoblast differentiation of hMADS cells
ORGANISM(S): Homo sapiens 
2008-08-08 | E-MARS-10 | biostudies-arrayexpress
GenomicsDual Functions of TAF7L in Adipocyte Differentiation
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and mouse white fat tissue (WAT). Depletion of TAF7L reduced adipocyte-spec...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-41937 | biostudies-arrayexpress
TranscriptomicsAdipocyte differentiation
Objective: Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available regarding the relationship of miRNAs expression profile, biological ...
ORGANISM(S): Homo sapiens 
2010-05-13 | E-GEOD-18469 | biostudies-arrayexpress
TranscriptomicsSRSF10 regulates alternative splicing and is required for adipocyte differentiation.
During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired devel...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
GenomicsThe Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
The Mediator complex functions as a control center orchestrating diverse signalings, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that direct...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-40369 | biostudies-arrayexpress
MetabolomicsAdipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_untargeted metabolites_Lipidomics

Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism involved in the regulation of lipid metabolic remodeling in the TAME remain...

2025-04-30 | MTBLS12289 | MetaboLights
MetabolomicsLipidomic profiling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation with oleic acid supplementation
This study investigated the lipidomic remodeling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation. Scd1 or Scd2 knockout cells and corresponding control cells were induced to undergo brown adipocyte-like differentiation for 96 h. To evaluate whether exogenous monounsat...
2026-06-23 | MTBLS14692 | MetaboLights
TranscriptomicsTranscription profiling of NIH3T3 cells over-expressing PPARg or EBF1 to study the efficiency and kinetics of cell adipogenesis induced by PPARg and EBF1.
NIH-3T3 cells transduced with either EBF1-, PPARg2- or empty vector were stimulated with hormones to initiate adipocyte differentiation. RNA extraction was done using TriZol at d0, d2, d4 and d10 after stimulation. Samples were handled according to standard affymetrix protocols. Keywords = Adipogene...
ORGANISM(S): Mus musculus 
2007-09-22 | E-GEOD-2192 | biostudies-arrayexpress
TranscriptomicsAdipocyte Differentiation of Immortalized Human Bone Marrow-derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222
Human bone marrow mesenchymal stromal cells are capable of limited self-renewal and multi-lineage differentiation in vitro. Several studies have demonstrated that microRNAs, post-transcriptional modifiers of protein expression, play crucial roles in the regulation of these complex processes. To gain...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-24898 | biostudies-arrayexpress
ProteomicsMouse adipocyte phosphoproteome during differentiation
Kosaku Shinoda, Kana Ohyama, Yutaka Hasegawa, Hsin-Yi Chang, David W. Scheel, Louis Z. Sharp, Haemin Hong, Takashi Hosono, Mayu Ogura, Ayaka Sato, Yasushi Ishihama, and Shingo Kajimura. Phosphoproteomics Identifies CK2 As a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-08-28 | MSV000079278 | MassIVE
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