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ProteomicsThe effect of proteasome inhibition on the HLA peptidome
The Major histocompatibility complex (MHC) class I peptidome is thought to be generated mostly through proteasomal degradation of cellular proteins, a notion that is based on the alterations in presentation of selected peptides following proteasome inhibition. We evaluated the effects of proteasome ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-27 | PXD000171 | Pride
Hla peptidome Proteasome inhibitors Dynamic silac 
ProteomicsThe nature and extent of contributions by defective ribosome products to the HLA peptidome
MHC class I peptides are products of endogenous cellular protein degradation. Their prompt presentation, after rapid degradation of their newly synthesized source proteins, is needed to alert the immune system during pathogen infection. A possible source for such rapidly degrading proteins can be de...
ORGANISM(S): Homo sapiens (Human) 
2018-05-17 | PXD009801 | Pride
Dripome Dynamic silac Immunopeptidome 
ProteomicsRanking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome
The Endoplasmic reticulum aminopeptidase I (ERAP1) trims peptides to their optimal size for binding to Major Histocompatibility Complex class I proteins. The natural polymorphism of this enzyme is associated with ankylosing spondylitis (AS) in epistasis with the major risk factor for this disease, H...
ORGANISM(S): Homo sapiens (Human) 
2018-04-10 | PXD008500 | Pride
Hla Mhc Peptidome Immunopeptidome Human Lc-ms/ms 
Proteomics,MultiomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080843 | MassIVE
ProteomicsThe effect of interferons on presentation of defective ribosome products as HLA peptides
The class I major histocompatibility complex (MHC) bound peptides, produced from immature proteins that are degraded rapidly are called defective ribosome products (DRiPs). Such DRiPs are possibly involved with early alerting of the immune system about impeding infections, thus bringing about faster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-25 | MSV000096209 | MassIVE
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsAllele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Birdshot chorioretinopathy (BSCR) is a rare inflammatory eye disease very strongly associated with HLA-A*29:02, with >95% of patients carrying this allele. BSCR is also associated with endoplasmic reticulum aminopeptidase (ERAP)2, an enzyme involved in processing HLA class I ligands. We analyzed the...
ORGANISM(S): Homo sapiens (Human) 
2018-05-17 | PXD007679 | Pride
Hla-a*29:02 Endoplasmic reticulum aminopeptidase 2 (erap2) Birdshot chorioretinopathy 
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
ProteomicsEditing the immunopeptidome of melanoma cells using a potent inhibitor of ER aminopeptidase 1
The efficacy of cancer immunotherapy, including treatment with immune-checkpoint inhibitors, is often limited by ineffective presentation of antigenic peptides that can elicit T-cell mediated anti-tumor cytotoxic responses. Therefore, manipulating antigen presentation is an emerging approach for enh...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD011766 | Pride
Inhibitor Immunopeptidome Erap1 
ProteomicsThe Behçet’s Disease associated Hap10 variant of ERAP1 generates a low affinity HLA-B*51 peptidome through differential processing of two subpeptidomes
HLA-B*51, the main risk factor for Behçet’s disease (BD), binds two main subpeptidomes consisting of low affinity peptides with Ala as their second amino acid and higher affinity peptides with Pro at this position. A low activity variant of ERAP1, Hap10, is uniquely associated with BD susceptibility...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006215 | Pride
Behçet's disease Erap1 Hla-b*51 Antigen processing 
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