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TranscriptomicsDicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex [RT-PCR]
MicroRNAs (miRNAs) are small, endogenous, non-protein coding RNAs that are an important means of post-transcriptional gene regulation. Deletion of Dicer, a key miRNA processing enzyme, is embryonic lethal in mice, and tissue-specific Dicer deletion results in developmental defects. Using a condition...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45810 | biostudies-arrayexpress
ProteomicsProteomic analysis of the extracellular matrix in the porcine adrenal cortex
The extracellular matrix (ECM) is a complex network of proteins that provides structural support and influences tissue boundaries, biomechanical properties, and cell polarity. This study analyzed the ECM profile of the porcine adrenal cortex's outer (OF = capsule + subcapsular + zona glomerulosa cel...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-07-14 | PXD055486 | Pride
Adrenal cortex Extracellular matrix Adrenal gland Porcine 
TranscriptomicsGenome wide analysis of Adrenal Gland tissue from Gata6 conditional knockout versus Control Adrenal tissue
Transcription factor GATA6 is expressed in the fetal and adult adrenal cortex and has been implicated in steroidogenesis. To characterize the role of GATA6 in adrenocortical development and function, we generated mice in which Gata6 was conditionally deleted using Cre-LoxP recombination with Sf1-cre...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-40398 | biostudies-arrayexpress
ProteomicsDecoding the human adrenal cortex matrisome: the composition and regulation of ECM proteins of the outer and inner microenvironment.
The extracellular matrix (ECM) comprises macromolecules that shape a complex three-dimensional network. Filling the intercellular space and playing a crucial role in the structure and function of tissues, ECM regulates essential cellular processes such as adhesion, differentiation, and cell signalin...
ORGANISM(S): Homo sapiens (Human) 
2024-09-11 | PXD051801 | Pride
Human adrenal gland Extracellular matrix Cortex Matrisome. 
TranscriptomicsAdrenal gene expression profiles of male and female Kcnk3 null mice in basal conditions or after hormonal treatment.
Primary aldosteronism (PA) is a common form of endocrine hypertension suspected in the presence of arterial hypertension (HT), hypokalemia and low plasma renin levels. While for a long time the genetic causes of PA have remained mysterious, recent findings have revealed an important role for an alte...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-37825 | biostudies-arrayexpress
ProteomicsThe extracellular matrix protein signatures of the outer and inner zone of the rat adrenal cortex
Different sites and changes in the tissue microenvironment have been associated with the cortex of adrenal gland functionality, maintenance, and renewal. Here we describe the differences between the extracellular matrix (ECM) signatures of the outer (OF) and inner fractions (IF) of the rat adrenal c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-09 | PXD046828 | Pride
Adrenal cortex Rat Extracellular matrix Adrenal gland 
Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
TranscriptomicsTranscription profiling of rat adrenal zona glomerulosa cells stimulated with aldosterone secretagogues
The mineralocorticoid aldosterone mainly produced by the adrenal gland is essential for life but an abnormal excessive secretion causes severe pathological effects including hypertension and target organ injury in the heart and kidney. The aim of this study was to determine the gene regulatory netwo...
ORGANISM(S): Rattus norvegicus 
2008-10-18 | E-GEOD-8421 | biostudies-arrayexpress
TranscriptomicsDicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45812 | biostudies-arrayexpress
ProteomicsMass spectrometry-based proteomics discovery of prognostic biomarkers in adrenal cortical carcinoma
Adrenal cortical carcinoma (ACC) is an extremely rare disease with a variable prognosis. Current prognostic markers have limitations in identifying patients with a poor prognosis. Herein, we aimed to investigate the prognostic protein biomarkers of ACC using mass-spectrometry-based proteomics. We pe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD027404 | Pride
Human Ffpe Lfq Adrenal cortical carcinoma Biomarkers 
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