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MetabolomicsUntargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity

OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metab...

2018-02-09 | MTBLS423 | MetaboLights
ProteomicsQuantitative age-specific variability of plasma proteins in healthy neonates, children and adults
Human blood plasma is a complex biological fluid containing soluble proteins, sugars, hormones, electrolytes, and dissolved gasses. As plasma interacts with a wide array of bodily systems, changes in protein expression, or the presence or absence of specific proteins are regularly used in the clinic...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005661 | Pride
Adult and children plasma Human plasma Swath Age 
MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
MetabolomicsAlterations in gut microbiota composition, plasma lipids, and brain activity, suggest inter-connected pathways influencing malnutrition-associated cognitive and neurodevelopmental changes.

Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions, with nearly half of child deaths under five linked to malnutrition. Survivors face lasting consequences, including impaired neurocognitive development, leading to cognitive and behavioura...

2024-11-27 | MTBLS10066 | MetaboLights
ProteomicsA new multiplexed plasma biomarker panel developed using targeted proteomics and machine learning has diagnostic and prognostic potential in children with hypertrophic cardiomyopathy
Background Hypertrophic cardiomyopathy (HCM) is defined clinically by pathological left ventricular hypertrophy (LVH). We have previously developed a plasma proteomics biomarker panel that correlates with clinical markers of disease severity and sudden cardiac death (SCD) risk in adult patients with...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045304 | Pride
Childhood-onset hcm proteomics 
TranscriptomicsIntermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in the adult rat through long-lasting programming effects
The long-term effects of neonatal intermittent hypoxia (IH), an accepted model of apnea-induced hypoxia, are unclear. We have previously shown lasting “programming” effects on the HPA axis in adult rats exposed to neonatal IH. We hypothesized that neonatal rat exposure to IH will subsequently re...
ORGANISM(S): Rattus norvegicus 
2016-01-07 | E-GEOD-74145 | biostudies-arrayexpress
TranscriptomicsWhole-blood MicroRNA Sequence Profiling for Adolescents with Postural Tachycardia Syndrome
Objective To establish whether whole-blood MicroRNA (miRNA) profiles differ between postural tachycardia syndrome (POTS) sufferers and control subjects, and to identify the miRNA that regulate plasma H2S. Study design: High-throughput sequencing was used to obtain whole-blood miRNA expression profi...
ORGANISM(S): Homo sapiens 
2022-06-07 | E-MTAB-10961 | biostudies-arrayexpress
ProteomicsMultisystem inflammatory syndrome in children (MIS-C) serum proteomics
While fewer cases of severe Coronavirus Disease 2019 (COVID-19) are reported globally in children, a small proportion of SARS-CoV-2 infected children develop a novel pediatric febrile entity called multisystem inflammatory syndrome in children (MIS-C) that develops 2 to 5 weeks after initial SARS-Co...
ORGANISM(S): Homo sapiens (Human) 
2021-09-29 | PXD025462 | Pride
Mis-c Proteomics Dia Serum Lc-ms 
TranscriptomicsPlasma profiling of miRNAs in mouse model of osteosarcoma.
Osteosarcoma (OS) is the primary bone tumor in children and young adults. Currently, there are no reliable, non-invasive biological markers to detect the presence or progression of disease, assess therapy response, or provide upfront prognostic insights. Using a qPCR-based platform that analyzes mo...
ORGANISM(S): Mus musculus 
2015-01-24 | E-GEOD-65236 | biostudies-arrayexpress
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