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TranscriptomicsmicroRNA profiling of fetal liver and adult bone marrow pro-B cells
We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression profiles of pro-B cells sorted from fetal liver and adult bone marrow in order to gain insight into changes in miRNA expression during B cell ontogeny. Fetal liver and adult bone marrow cells were harvest...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35107 | biostudies-arrayexpress
TranscriptomicsLin28b expression distinguishes fetal versus adult lymphopoiesis
This SuperSeries is composed of the following subset Series: GSE35081: miRNA profiling of double-positive thymocytes transduced with a retrovirus encoding Lin28a compared to untransduced controls GSE35107: microRNA profiling of fetal liver and adult bone marrow pro-B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35214 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Local renin antiotensin systems have been identified for many extra-renal sites. Bone marrow has been proposed as one such site, although the nature of the renin-expressing cell type(s) has not been established. Affymetrix microarrays were used to characterize the expression profile of renin-express...
ORGANISM(S): Mus musculus 
2014-02-17 | E-GEOD-53916 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bone marrow derived and trabecular bone osteogenic cells - 0
This SuperSeries is composed of the following subset Series:; GSE12264: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone I; GSE12265: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone II; GSE12266: Gene Expres...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12267 | biostudies-arrayexpress
TranscriptomicsT cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteogenic cells derived from bone marrow and trabecular bone - II
The aim of this study was to describe the gene expression patterns related to the differentiation and mineralization of bone-forming cells, including activation and/or repression of osteogenic or non-osteogenic pathways, remodeling of cell architecture, cell adhesion, cell communication, and assembl...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12265 | biostudies-arrayexpress
TranscriptomicsGeneration of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells
Reprogramming of somatic cells provides potential for the generation of specific cell types, which could be a key step in the study and treatment of human diseases. In vitro reprogramming of somatic cells into a pluripotent embryonic stem (ES) cellM-bM-^@M-^Slike state has been reported by retrovira...
ORGANISM(S): Mus musculus 
2009-07-02 | E-GEOD-15775 | biostudies-arrayexpress
TranscriptomicsScf-GFP+ cells from the bone marrow and whole bone marrow microarray
The HSC niche factor SCF is required for HSC maintenance. Using an Scf-GFP knockin mouse, we have identified a perivascular cell type in the bone marrow expressing high level of Scf. To characterize the novel Scf-GFP+ cells from the bone marrow, we performed microarray analysis on these cells. Total...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-33158 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of double-positive thymocytes transduced with a retrovirus encoding Lin28a compared to untransduced controls
We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression in double-positive (DP) thymocytes that developed in the presence (GFP+) or absence (GFP-ve) of ectopic mLin28 expression. Transduced (GFP+) and untransduced (GFP-ve) CD4+ CD8+ CD3- thymocytes were FACS s...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of GR-N-91 neuroblasts injected subcutaneously into nude mice and a primary tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were isolated from Myocardium (MY) and Bone Marrow (BM)
We have used an IGR-N-91 parental cell line established from an involved bone marrow harvested from a high-risk NB (stage 4-NB, 8 year-old boy). These IGR-N-91 neuroblasts were injected subcutaneously into nude mice and a Primary Tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were...
ORGANISM(S): Homo sapiens 
2006-09-11 | E-TABM-44 | biostudies-arrayexpress
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