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ProteomicsGATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation endproducts
Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacterized catalytic activities. Recent forward genetics approaches have at...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-02 | PXD030977 | Pride
Glycation Advanced glycation endproduct Glutamine amidotransferase Deglycase Dj-1 Mitochondria Molecular evolution Co-immunoprecipitation Park7 
TranscriptomicsDifferential Expression of Ove26(Diabetic) vs FVB(Nondiabetic) mice
Objective – Previous studies showed that genetic deletion or pharmacological blockade of the Receptor for Advanced Glycation Endproducts (RAGE) prevents the early structural changes in the glomerulus associated with diabetic nephropathy (DN). To overcome limitations of mouse models that lack the pr...
ORGANISM(S): Mus musculus 
2011-02-22 | E-GEOD-20844 | biostudies-arrayexpress
ProteomicsGATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation endproducts
Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacterized catalytic activities. Recent forward genetics approaches have at...
ORGANISM(S): Homo sapiens (Human) Escherichia coli (strain K12) 
2022-03-02 | PXD030978 | Pride
Glycation Advanced glycation endproduct Fplc Glutamine amidotransferase Deglycase Dj-1 Mitochondria Molecular evolution Park7 In gel digestion 
UnknownAdvanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response.
Not available
S-EPMC1182551 | biostudies-literature
UnknownChemical Reactivity Theory Study of Advanced Glycation Endproduct Inhibitors.
Not available
S-EPMC6155735 | biostudies-literature
TranscriptomicsPlatelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor
Platelets contain abundant miRNAs, however, the biogenesis pathway of miRNAs in anucleate platelets is unclear. Platelet-rich plasma was diluted in washing buffer and the platelet suspension was centrifuged to isolated pure platelets.Finally, platelets were recovered in suspension buffer at the conc...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-51453 | biostudies-arrayexpress
TranscriptomicsAger (Rage) and Myd88 deletion in resected mouse livers
The effect of resection of mouse livers on survival serve as a model for the effect of resection of human livers, which are performed for both the purposes of removing sick tissue and for transplanting healthy tissue. When less than 70% of a mouse liver is resected, the mouse usually lives. However,...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-22873 | biostudies-arrayexpress
UnknownGalectin-3 and RAGE differentially control advanced glycation endproduct-induced collagen damage in murine intervertebral disc organ culture.
Not available
S-EPMC10285763 | biostudies-literature
GenomicsRAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity
The spread of SARS-CoV-2 has fuelled the COVID-19 pandemic with its enduring medical and socioeconomic challenges due to subsequent waves and long-term consequences of great concern. Here we chart the molecular basis of COVID-19 pathogenesis, by analysing patients’ immune response at single-cel...
EGAS00001007529 | EGA
ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
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