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ProteomicsGATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation endproducts
Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacterized catalytic activities. Recent forward genetics approaches have at...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-02 | PXD030977 | Pride
Glycation Advanced glycation endproduct Glutamine amidotransferase Deglycase Dj-1 Mitochondria Molecular evolution Co-immunoprecipitation Park7 
ProteomicsGATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation endproducts
Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacterized catalytic activities. Recent forward genetics approaches have at...
ORGANISM(S): Homo sapiens (Human) Escherichia coli (strain K12) 
2022-03-02 | PXD030978 | Pride
Glycation Advanced glycation endproduct Fplc Glutamine amidotransferase Deglycase Dj-1 Mitochondria Molecular evolution Park7 In gel digestion 
UnknownDeglycase-activity oriented screening to identify DJ-1 inhibitors.
Not available
S-EPMC8292988 | biostudies-literature
UnknownKinetic evidence in favor of glyoxalase III and against deglycase activity of DJ-1.
Not available
S-EPMC10127264 | biostudies-literature
UnknownDJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.
Not available
S-EPMC9539984 | biostudies-literature
UnknownGATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products.
Not available
S-EPMC8935817 | biostudies-literature
UnknownInsights into the catalytic mechanism of a bacterial deglycase essential for utilization of fructose-lysine.
Not available
S-EPMC10285752 | biostudies-literature
UnknownThe apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals.
Not available
S-EPMC6901308 | biostudies-literature
UnknownPARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function.
Not available
S-EPMC10634309 | biostudies-literature
UnknownSerendipitous Discovery of a Competitive Inhibitor of FraB, a Salmonella Deglycase and Drug Target.
Not available
S-EPMC9609667 | biostudies-literature
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