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MetabolomicsAdjunctive ibuprofen in pre-extensively drug-resistant and extensively drug-resistant tuberculosis: a Phase IIA open-label pilot clinical trial

Drug-resistant tuberculosis (TB) remains a major global health challenge. Host-directed therapies (HDTs) aim to limit tissue damage, shorten treatment, and improve outcomes by modulating immune responses. We evaluated the safety and potential efficacy of adjunctive ibuprofen an inexpens...

2026-05-28 | MTBLS13376 | MetaboLights
ProteomicsDetection and Quantification of Drug-Protein Adducts in Human Liver
Protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, toxicity and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due to lack of methods capable of discovering the proteins and peptides adducted by re...
ORGANISM(S): Homo Sapiens Spodoptera Frugiperda 
PXD054246 | panorama
UnknownDrug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management.
Not available
S-EPMC7050640 | biostudies-literature
UnknownData mining techniques for detecting signals of adverse drug reaction of cardiac therapy drugs based on Jinan adverse event reporting system database: a retrospective study.
Not available
S-EPMC9872458 | biostudies-literature
UnknownAge-Associated Risk of Liver-Related Adverse Drug Reactions.
Not available
S-EPMC8968752 | biostudies-literature
UnknownMining drug-target and drug-adverse drug reaction databases to identify target-adverse drug reaction relationships.
Not available
S-EPMC8533369 | biostudies-literature
UnknownPreventability and manageability of adverse drug reactions in COVID-19 with mucormycosis: An observational study.
Not available
S-EPMC11504753 | biostudies-literature
UnknownSystematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.
Not available
S-EPMC1463974 | biostudies-literature
UnknownUse of a Patient-Friendly Terms List in the Adverse Drug Reaction Report Form: A Database Study.
Not available
S-EPMC6581931 | biostudies-literature
TranscriptomicsVitamin C Stimulon in Mycobacterium tuberculosis
The emergence of drug resistance among tuberculosis (TB) patients is often associated with their non-compliance to the length of the chemotherapy, which can reach up to 2 years for the treatment of multi-drug-resistant (MDR) TB. Drugs that would kill TB faster and would not lead to the development ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-05-24 | E-GEOD-42293 | biostudies-arrayexpress
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